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强直性脊柱炎免疫遗传学和发病机制研究进展 被引量:12

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摘要 强直性脊柱炎(AS)是一主要累及青壮年的常见疾病,其发病率和致残率高,探索其发病机制非常重要。目前关于AS的发病机制存在多个不同的假设,其中研究较多并且具有一定意义的假设包括:(1)HLA-B27在AS的发病机制和遗传潜质中占有非常重要的地位,AS与B27之间的强相关性已经得到公认并且被广泛证实,其中流行病学研究显示HLA-B27与AS的这种相关性遍及全世界,其中的重要证据之一是一级亲属是AS的HLA-B27阳性个体患病的风险是无家族史的B27阳性个体的6~16倍;(2)MHC基因也被认为可能参与了AS的发病,其中可能的候选基因可能定位于第2号、第9号和第16号染色体,其中TNF-α850和HLA-B13、B27、CE6等基因可能是AS患者的易感基因;(3)其他新的遗传易感基因如PD1的基因多态性与AS易感性之间存在遗传关联;(4)细菌感染与AS之间相关性的一些重要证据来源于动物模型,认为细菌感染与HLA-B27之间的作用可能是致病的一个关键因素;(5)Ⅱ型胶原、蛋白聚糖是软骨的成分,目前认为它们可能是AS自身免疫反应的候选目标;(6)AS的发病机制还包括T细胞的功能特别是调节性T细胞亚群中CD4^+ CD25^+Treg的功能、骨生成蛋白、前列腺素、内皮细胞及内皮素的功能异常和瘦素等因素均可能参与了AS的炎症反应过程。
作者 杨春花 黄烽
出处 《现代免疫学》 CAS CSCD 北大核心 2007年第4期265-269,共5页 Current Immunology
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参考文献19

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二级参考文献7

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