摘要
目的：探讨静脉丙种球蛋白预防早产儿感染的临床疗效。方法：116例早产儿随机分为两组,治疗组60例,对照组56例,两组基础治疗相同,治疗组生后48h内应用静脉丙种球蛋白400mg/kg,连用2-3d。分别观察感染发生率、抗生素使用天数、病情稳定天数、住院天数。结果：治疗组感染发生率为8.3%,对照组为21.4%,两组比较差异有统计学意义（P〈0.05）;治疗组和对照组抗生素应用天数分别为（3.6±2.04）d、（6.1±5.36）d,住院天数分别为（9.3±4.25）d、（14.1±8.61）d,两组相比差异均有统计学意义（P〈0.01）。结论：早产儿预防性应用静脉丙种球蛋白,可减少感染发生率,缩短抗生素应用天数、病情稳定天数、住院天数,值得临床推广。
Objective： To study the clinical effects of IVIG in preventing preteml infecton. Methods： One hundred and sixteen preterm were randomly divided into a control group of 56 cases and a treatment group of 60 cases. Two groups were given regular treatment, with the treatment group having additional IVIG, the dose of which was 400 mg/kg administrated within 48 hours after birth for two or three days, and then the durations of antibiotics used, the days of patients condition stabilized, the durations of hospitalization were compared between the two groups. Results： The rate of infection in the treatment group was 8.3 % while in the control group was 21.4%. There was a significant difference between two groups （ P 〈 0.05）. There was also significant difference in the duration of administration of antibiotics （3.6 ± 2.04, 6.1 ±5.36） （P 〈 0.01） and the duration of hospitalization （9.3± 4.25, 14.1 ±8.61 ） （P 〈 0.01 ）. Conclusions： The application of IVIG to pretem＇s can reduce the rate of infection, shorten the duration of antibiotics used, the days of patients condition stabilized, the duration of hospitalization and so worth promoting.
出处
《儿科药学杂志》
CAS
2007年第4期59-60,共2页
Journal of Pediatric Pharmacy
