摘要
乳腺干细胞不仅对乳腺的发生、分化和功能维持起到重要作用,而且近年来发现乳腺干细胞与乳腺癌的发生也有密切联系,有研究报道乳腺干细胞是乳腺癌发生的始动靶点,迄今为止,还没有明确的乳腺干细胞标记物研究报道,因此大多数学者都依靠在造血、神经、表皮或其它系统中的干细胞标志去研究乳腺干细胞。本文对乳腺干细胞标记物的最新进展及其在乳腺癌发生中的作用作一综述。
Mammary gland stem cells not only play an important role in the development, differentiation and funelion of the mammary gland, but they are also associated with breast carcinogenesis and recently they have been shown to be the targets of transformation during breast carcinogenesis. Until now there have been no speeifie mammary gland stem cell markers, so researchers rely on stem cell markers borrowed from hematopoietic, neural, epidermal and other systems to search for stem cells in mammary glands. This article reviews the research progression of mammal7 gland stem cell markers and their role in breast carcinogenesis.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2007年第15期874-876,共3页
Chinese Journal of Clinical Oncology
基金
天津市科委重大科技基金项目资助(编号:043115211-1)
关键词
乳腺
干细胞
标记物
乳腺癌
mammary gland
slem cell
marker
breast cancer
