期刊文献+

21例胃肠间质瘤诊治分析 被引量:6

Diagnosis and Treatment of Gastrointestinal Stromal Tumors in 21 Patients
下载PDF
导出
摘要 目的 探讨胃肠间质瘤(gastrointestinal stromal turnor,GIST)的临床特点。方法 1993—2006年收治的21例GIST患者的临床表现,手术处理及病理检查结果进行回顾性分析。结果 21例进行手术治疗,病理诊断为良性8例,恶性3例,低度恶性10例。随访14例,随访时间:0.5~13年,10例转移或局部复发并死亡。结论 GIST缺乏特征性临床表现,术前确诊率低,其确诊依赖病理检查。目前,GIST的治疗以手术切除为主。 Objective To explore the clinical characteristics of gastrointestinal stromal tumors (GIST). Methods The clinical manifestations,surgical treatments and pathologic examination findings of 21 patients with gastrointestinal stromal tumors, who were in our hospital from 1993 to 2006 ,were analyzed retrospectively. Results Surgical interventions were performed on 21 patients with GISTs, among which eight cases were benign,3 were malignant and 10 were low potential malignancies by pathologic diagnosis. Fourteen of twenty-one patients were followed-up from 6 months to 13 years. Ten patients suffered from malignant tumor metastasis or tumor relapse in situ, and died of GIST, Conclusions The clinical situations of GIST have not specificity, so the ratio of preoperative definite diagnosis is low. The final diagnosis of GIST depends on pathological examination. In present, the optimal treatment of GIST is exairesis of tumors.
出处 《实用全科医学》 2007年第9期784-785,共2页 Applied Journal Of General Practice
关键词 胃肠道间质瘤 间叶性肿瘤 Gastrointestinal stromal tumor Mesenchymal tumor
  • 相关文献

参考文献7

二级参考文献83

  • 1田忠,勾健,赵海鹰,杨福全,乔麟,刘源,孙思予,王孟春,刘金钢.腹腔镜微创外科治疗胃间质瘤17例报告[J].中国实用外科杂志,2006,26(2):131-132. 被引量:22
  • 2Isozaki K,Terris B,Belghiti J,et al.Germline-activating mutation in the kinase domain on KIT gene in familial gastrointestinal stromal tumors[J].Am J Pathol,2001,157(5):1581-1585.
  • 3Miettinen M,Sobin LH,Sarlomo-Rikala M,et al.Immunohistochemical spectrum of gastrointestinal stromal tumors at different sites and their differential diagnosis with other tumors with a special reference to CD117 (KIT)[J].Mod Pathol,2000,13(10):1134-1142.
  • 4Tsujimura T,Makiishi-Shimobayashi C,Lundkvist J,et al.Expression of the intermediate filament nestin in gastrointestinal stromal tumors and interstitial cells of Cajal[J].Am J Pathol,2001,158(3):817-823.
  • 5Lux ML,Rubin BP,Biase TL,et al.KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors[J].Am J Pathol,2000,156(3):791-795.
  • 6Heinrich MC,Corless CL,Duensing A,et al.PDGFRA activating mutations in gastrointestinal stromal tumors[J].Science,2003,299(5607):708-810.
  • 7Dematteo RP,Heinrich MC,El-Rifai WM,et al.Clinical management of gastrointestinal stromal tumors:before and after STI-571[J].Hum Pathol,2002,33(5):466-477.
  • 8Joensuu H,Roberts PJ,Sarlomo-Rikala M,et al.Effect of the tyrosine kinase inhibitor STI 571 in a patient with a metastatic gastrointestinal stromal tumor[J].N Engl J Med,2001,344(14):1052-1056.
  • 9van Oosterom AT,Judson I,Verweij J,et al.Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours:a phase I study[J].Lancet,2001,358(9291):1421-1423.
  • 10Demetri GD,von Mehren M,Blanke CD,et al.Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors[J].N Engl J Med,2002,347(7):472-480.

共引文献84

同被引文献47

引证文献6

二级引证文献31

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部