摘要
目的测定血清甲胎蛋白(AFP)和细胞间黏附分子-1(ICAM-1)在肝细胞肝癌(HCC)复发前后的变化,探讨其在复发监测中的价值。方法对手术后复发的44例肝癌患者的血AFP与ICAM-1水平进行回顾性研究分析。结果当确诊为肝癌复发时,AFP的水平明显低于术前(P<0.01),ICAM-1的水平低于术前(P<0.05);AFP阳性例数为23例,Ⅰ- CAM-1阳性例数为36例,ICAM-1的阳性率高于AFP(P<0.01),两者中任一项阳性病例共42例,高于ICAM-1(P<0.05)或AFP(P<0.05)单独的阳性率。结论肝癌复发早期诊断中,ICAM-1的意义大于AFP,尤其是AFP阴性的患者,两者联合检测的价值高于两者任何之一。
Objective To determination the clinical value of serum α-fetoprotein（AFP） and intercellular adhesion molecule-1（ICAM-1）in monitoring postoperative recurrence of hepatocellular carcinoma（HCC）. Methods Retrospectively analysed the level of plasma AFP and ICAM-1 of 44 patients who had been suffered from the hepatic carcinoma operation and relapse. Results When the recurrence was confirmed,the level of AFP was much lower significantly than the level before operation（P〈0.01） ;the level of ICAM-1 was lower significantly than the level before operation（P〈0.05）. The patients of positive AFP were 23,while ICAM-1 were 36,the positive rate of ICAM-1 was higher than the AFP（P〈0. 01）,and any one of the two parameters were 42,the positive rate was higher than anyone of the twoparameters（P〈0. 05）. Conclusion When the early diagnosis of the recurrence of hepatic carcinoma after operation can be needed,the worth of ICAM-1 is greater than the AFP,particularly for those patients with AFP negative and when the two parameters are combined ,the worth much greater than anyone.
出处
《现代检验医学杂志》
CAS
2007年第4期83-84,共2页
Journal of Modern Laboratory Medicine
