高敏C反应蛋白在骨关节炎早期诊断意义的探讨被引量：5

Study of Significance of Hypersensitive CRP in Patients with Early Osteoarthritis

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摘要目的:通过对健康体检人群、骨关节炎(OA)早期患者血浆高敏CRP(hs-CRP)水平的检测,探讨高敏C-反应蛋白在骨关节炎的早期诊断中的意义。方法:应用免疫透射比浊法检测和比较我院80例健康体检人群、89例骨关节炎早期患者hs-CRP水平,同时测量和比较两组的血糖、血脂、血尿酸、血沉、体重指数、腰/臀比和血压。记录骨关节炎早期患者关节肿胀数目等受累情况,并进行分析。结果:OA患者血浆hs-CRP水平明显高于健康对照组,OA患者血浆hs-CRP水平阳性率为62.9%(56/89),hs-CRP与骨关节炎患者关节肿胀数目、疼痛程度呈正相关。结论:hs-CRP在骨关节炎早期阶段可能具有诊断意义。 To explore the significance of plasma high sensitivity CRP in diagnosing of the early osteoarthritis throngh examining the level of high sensitivity CRP between healthy and patients of osteoarthritis. Methods： Hs-CRP, blood glucose, blood fat, blood sedimentation, body mass index, waist circumference/hip circumference and blood pressure in each group were measured. Joints involved of osteoarthritis patients were observed and analyzed. Results： The level of plasma hs-CRP in the early osteoarthritis and in control gt＇oup was 3. 61（0. 85～10. 65）mg/L and 2. 37（0.23～4. t6）mg/L respectively. There was significant difference between the two groups （P〈0. 01）. A strong association between the level of plasma hs-CRP in the early osteoarthritis and number of swelling joints, extend of pain. Conclusions： The level of plasma hsCRP maybe play an important role in the early diagnosis of osteoarthritis.

作者尚桂莲徐焱成

机构地区武汉大学医学院武汉大学中南医院内分泌风湿科

出处《数理医药学杂志》 2007年第4期475-478,共4页 Journal of Mathematical Medicine

关键词高敏C-反应蛋白骨关节炎早期诊断 osteoarthritis high sensitivity CRP early diagnosis

分类号 R684.3 [医药卫生—骨科学]

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