摘要
目的探讨血液灌流对重型肝炎的疗效。方法应用HA型血液灌流器对31例重型肝炎患者进行血液灌流66次。观察患者临床症状、血清内毒素、细胞因子、肝肾功能、电解质、凝血酶原活动度(PTA)、血氨和血常规的变化以及治疗组与对照组疗效的比较。结果血液灌流后,患者临床症状均得到不同程度的改善。内毒素、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)明显降低(P<0.01),血清总胆红素、血氨较治疗前明显降低(P<0.01或P<0.05),血液灌流组的好转率显著高于对照组(P<0.05)。血小板减少(P<0.05),不良反应较轻。结论血液灌流能吸附重型肝炎患者血液中胆红素、内毒素及细胞因子,是治疗重型肝炎的一种安全、有效的方法,可提高早、中期重型肝炎的抢救成功率。
Objective In order to study the clinical efficacy of hemoperfusion in severe liver diseases. Methods 31 patients with severe liver diseases were treated with HA hemoperfusion cartridge for 66 times. The resuits of serum endotoxin, cell factors, liver function, renal function, electrolyte, prothrombin time activity （ PTA ）, blood ammonia, blood routine before and after the treatment were analyzed. The effective rate of hemoperfusion group was compared to the control group. Results After hemoperfusion,symptoms of patients with severe liver diseases were improved. Serum endotoxin, tumor necrosis factor alpha （ TNF-α ）, interleukin- 6 （ IL- 6 ） obviously reduced （ P 〈 0. 01 ）, serum bilirubin, blood ammonia also obviously reduced than before （ P 〈 0.05 or P 〈 0.01 ）. The effective rate of hemoperfusion group was significantly higher than control group（ P 〈 0.05 ）. Blood platelet （PLT） reduced（ P 〈 0.05 ） , tbe side effects were mild. Conclusion Serum bilirubin,endotoxin, cell factors can be absorbed by hemoperfusion, which is comparatively safe and effective in the treatment of severe liver diseases. And hemoperfusion can elevate the survival rate of patients with severe liver diseases in early or middle period.
出处
《透析与人工器官》
2007年第2期13-16,共4页
Chinese Journal of Dialysis and Artificial Organs
关键词
血液灌流
重型肝炎
内毒素
细胞因子
hemoperfusion
severe liver diseases
endotoxin
cell factors
