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脑缺血再灌注损伤后血脑屏障通透性研究进展 被引量:6

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摘要 血-脑屏障(blood brain barrier,BBB)为中枢神经系统毛细血管腔与神经组织之间存在的所有结构,是脑与血液及脑脊液之间的一种屏障,与中枢神经的变性、损伤和炎症密切相关[1-3].一般来说,BBB包括三部分:BBB、血-脑脊液屏障(blood cerebrospinal fluid barrier,BLB)和脑脊液-脑屏障(cerebrospinal fluid brain barrier,LBB),其中BBB和BLB屏障解剖结构有类似之处,生理和病理意义重大.BBB的组织结构包括脑毛细血管内皮细胞(brain microvessel endothelial cells,BMECs)及其间的紧密连接(tight junction,TJ)、基膜和周细胞、星型胶质细胞终足形成的胶质膜和细胞外基质(extracelluler matrix,ECM).
出处 《中日友好医院学报》 2007年第4期238-240,共3页 Journal of China-Japan Friendship Hospital
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参考文献24

  • 1Zheng W.Neurotoxicology of the brain barrier system:new implications[J].J Toxicol Clin Toxicol,2001,39(7):711-719.
  • 2Cucullo L,McAllister MS,Kight K,et al.A new dynamic in vitro model for the multidimensional study of astrocyte-endothelial cell interactions at the blood brain barrier[J].Brain Res,2002,951 (2):243-254.
  • 3Marchi N,Fazio V,Cucullo L,et al.Serum tranathyretin monomer as a possible marker of blood-to-CSF barrier disruption[J].J Neurosci,2003,23 (5):1949-1955.
  • 4金泽武道,蒲传强.脑缺血后血脑屏障超微结构的研究[J].中华神经精神科杂志,1994,27(2):67-69. 被引量:27
  • 5Neumann-Haefelin T,Kastrup A,de Crespigny A,et al.Serial MRI after tran-sient focal cerebral iscbemia in rats:dynamics of tissue injury,blood-brain barrier damage,and edema formation[J].Stroke,2000,31 (8):1965.
  • 6Prestigiacomo CJ,Kim SC,Connolly ES,et al.CD18 mediated neutrophil recruitment contributes to the Pathogenesis of reperfused but not nonreperfused stroke[J].Stroke,1999,30(5):1110-1117.
  • 7Ullian EM,Sapperstein SK,Chirstopherson KS,et al.Control of synapse number by glia[J].Science,2001,291:657-661.
  • 8Gong C,Qin Z,Betz AL,et al.Cellular localization of tumor necrosis factor alpha following focal cerebral in mice[J].Brain Res,1998,80(1~2):1-8.
  • 9沈强,刘亚敏,张赐安.麝香、冰片对全脑缺血再灌注大鼠脑微血管内皮细胞ICAM-1表达的影响[J].中西医结合心脑血管病杂志,2003,1(3):136-138. 被引量:42
  • 10Uno H,1VHtsuyama T,Akita H,et al.Induction of tumor necrosis factor-a in the mouse hippocampus following transient forebrain ischemia[J].J Cereb Blood Flow Metab,1997,17(5):491-499.

二级参考文献69

  • 1朱秀媛,高益民,李世芬.人工麝香的研制[J].中成药,1996,18(7):38-41. 被引量:26
  • 2[1]BALLABH P,BRAUN A,NEDERGAARD M.The blood-brain barrier:an overview:structure,regulation,and clinical implications[J].Neurobiol Dis,2004,16(1):1-13.
  • 3[2]SHUSTA E V.Blood-brain barrier genomics,proteomics,and new transporter discovery[J].NeuroRx,2005,2(1):151-161.
  • 4[3]SZABO C A,DELI M A,NGO T K,et al.Production of pure primary rat cerebral endothelial cell culture:a comparison of different methods[J].Neurobiology (Bp),1997,5 (1):1-16.
  • 5[4]BOADO R J,PARDRIDGE M M.A one-step procedure for isolation of poly(A) + mRNA from isolated brain capillaries an endothelial cells in culture[J].J Neurochem,1991,57:2136-2139.
  • 6[5]SCHENA M,SHALON D,DAVIS R W,et al.Quantitative monitoring of gene expression patterns with a complementary DNA microarray[J].Science,1995,270:1304-1351.
  • 7[6]DIATCHENKO L,LAU Y F,CAMPBELL A P,et al.Suppression subtractive hybridization:a method for generating differentially regulated or tissue-specific cDNA probes and libraries[J].Proc Natl Acad Sci USA,1996,93(12):6025-6030.
  • 8[7]VELCULESDU V E,ZHANG L,VOGELSTEIN B,et al.Serial analysis of gene expression[J].Science,1995,270:484-487.
  • 9[8]PARDRIDGE W M.Molecular biology of the blood-brain barrier[J].Mol Biotech,2005,30(1):57-69.
  • 10[9]PARDRIDGE W M Blood-brain barrier genomics and the use of endogenous transporters to cause drug penetration into the brain[J].Curr Opin Drug Discuv Devel,2003,6(5):683-691.

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