摘要
目的:观察婴幼儿血管瘤中免疫细胞的分布及其变化过程。方法:52例婴幼儿血管瘤标本,以CD3、CD8、S-100分别作为T细胞、细胞毒性T细胞(Tc细胞)和树突细胞(DC)的标记性抗原,采用免疫组化染色观察上述免疫细胞在血管瘤组织中的分布。结果:①最早期血管瘤组织中基本无CD3+T细胞;增殖中期CD3+T细胞增多,CD8+T细胞仍然稀少;增殖晚期CD3+T细胞很多,CD8+T细胞也增多;消退早期在微血管周围仍散在分布少量CD3+T细胞和CD8+T细胞;消退中期和消退完成期血管瘤组织中有少数CD3+T细胞,而CD8+T细胞很少。②增殖早期血管瘤组织中散在分布少量DC;增殖中期和晚期DC数量显著增多。消退早期之后,DC数量迅速减少,以至基本消失。结论:T细胞及其亚群和DC的分布及其功能变化,与血管瘤病理演变过程有密切联系,婴幼儿免疫系统功能逐渐成熟,可能是血管瘤消退的主要原因之一。
Objective ：To investigate the distribution and evolution of immunocytes in infantile hemangioma（IH）. Methods：Fifty-two infantile hemangioma samples were investigate. The distribution of CD3 ^＋T cells, CD8 ^＋T cells and S-100 ^＋ dendritic cell （DC） in IH was observed with. Results ：CD3 ^＋T cell was not found among the earliest IH. In the middle proliferating stage, the number of CD3 ^＋T cells increased ; But the CD8 ^＋T cells were still scare. In the late proliferating stage, there were many CD3 ^＋T cells and the number of CD8 ^＋ T cells also increased. In the early involuting stage, there were still a number of CD3 ^＋ and CD8 ^＋ T cells around the microvessels. In the middle involuting and involuted stage, only a few of CD3 ^＋T cells and CD8 ^＋T cells existed. In the During the middle and late proliferating stage, the early proliferating stage, there were some DC in IH. number of DC increased significantly. Since the earlyinvoluting stage, the DC. decreased rapidly and disappeared. Conclusion：The distribution of T cells and its subsets and DC have close relationship with the pathologic evolution of infantile hemangioma.
出处
《医学研究生学报》
CAS
2007年第7期720-722,789,共4页
Journal of Medical Postgraduates
基金
国家自然科学基金资助课题(批准号:30571928)
