摘要
目的探讨妊娠期急性脂肪肝(AFLP)的临床特点,以便早期诊断和及时治疗,降低孕产妇及围生儿的死亡率。方法对近4年我院收治的10例妊娠期急性脂肪肝患者的临床资料进行回顾性分析。结果9例患者为初产妇,平均发病孕周为36+6周,单胎8例,双胎2例。4例存活孕妇均行剖宫产结束分娩,3例入院时出现凝血功能障碍行剖宫产加子宫全切。孕产妇共存活4例,死亡率为60%;围生儿死亡9例,死亡率为75%。结论妊娠急性脂肪肝是发生在妊娠晚期的一种严重并发症,早期诊断、尽快终止妊娠是提高母儿预后的关键;对于AFLP患者的分娩方式选择我们主张以剖宫产尽快结束分娩为宜;对于出现凝血功能障碍者,应在剖宫产的同时行子宫全切,以挽救患者生命。
Objective： To explore the clinical features of acute fatty liver of pregnancy （AFLP） so that to diagnose and manage timely and correct diagnosis and treatment may decrease maternal mortality. Method： The clinical findings and outcome of pregnancy were analyzed in 10 patients with acute fatty liver of pregnancy at our hospital in recent 4 years. Results： Nine cases of AFLP were primiparas. The mean gestational age at onset was 36^＊6 weeks. Eight cases of AFLP were single birth and two cases were twins. Four survival pregnant women of AFLP were taking cesarean for termination of pregnancy and three cases were taking cesarean and uterus cutting for coagulation disorders as soon as they had hospital admission. The survival puerperas of AFLP were four cases in all and the mortality of puerperas were 60 percent, Nine neonates were dead and the mortality of neonates were 75 percent. Conclusion ： AFLP is a rare, potentially fatal disease that occurs in the late third trimester. The key point to decrease the rate of maternal deaths and stillborn is to understand its characters, to make early diagnosis and end the pregnancy timely. We maintained that cesarean should be taken as soon as possible for early termination of pregnancy. With the cases of coagulation disorders should be taken cesarean and uterus cutting to save the lives of patients.
出处
《中国优生与遗传杂志》
2007年第8期59-60,共2页
Chinese Journal of Birth Health & Heredity
