摘要
以奶山羊为试验动物,按体重灌服氟化钠复制奶山羊氟病模型,通过对一氧化氮自由基代谢的检测,进一步深入地探讨氟病的发生机理。结果表明:氟可促进机体生成一氧化氮自由基,对机体造成一系列损伤,构成了氟损伤机体的病理学基础。
Twelve dairy goats were divided into two study groups. Group Ⅰ was the control and group Ⅱ were fed sodium with fluoride（NaF） by oral according to their bodyweight. After 12 months of fluoride dosing, dairy goats of group Ⅱ showed clinical signs of fluorosis, all dairy goats were euthanized and their tissues and blood samples were taken for analyses. The tissues included brain, liver,spleen, kidney. The principal focus of this study was to clarify functions of nitric oxide in the mechanism of chronic fluorosis in dairy goat. It can be concluded that fluorine induces excessive nitrogen free radical which contribute to the pathogenesis of fluoride - induced injuries in organism.
出处
《黑龙江畜牧兽医》
CAS
北大核心
2007年第8期33-34,共2页
Heilongjiang Animal Science And veterinary Medicine
关键词
奶山羊
一氧化氮
氟病
Dairy goat
chronic fluorosis
nitric oxide
