摘要
目的原发性松果体区绒毛膜癌罕见,本文报道2例,探讨其诊断、治疗和预后。方法2例经病理证实的原发性松果体区绒毛膜癌,术前均有血清人绒毛膜促性腺激素(HCG)显著升高,分别为128935.7mIU/ml和9088.9mIU/ml,甲胎蛋白均为阴性。采用显微手术全切肿瘤,神经内镜下三脑室底造瘘术治疗术后脑积水。2例患者术后均联合化疗及放疗。结果2例患者肿瘤均全切除,脑积水缓解。经辅助治疗后血清HCG水平降至正常,术后两年磁共振检查无复发,血清HCG检查1例正常,另1例略高于正常。结论HCG检测对绒毛膜癌的诊断和治疗后监测非常重要,该病治疗应采用积极的手术全切除和术后综合治疗手段,可获得理想的疗效。
We report two rare cases of primary choriocarcinoma in the pineal region verified histo!ogically. In both cases, the pre-operative serum level of human chorionic gonadotropin （HCG） was significantly elevated to 128 935.7 and 9 088.9 mIU/ml, respectively, and serum alpha-fetoprotein （AFP） was negative. The tumors were microsurgically removed, and postoperative hydrocephalus were treated by endoscopic third ventriculostomy. Both patients underwent chemotherapy and radiotherapy. After adjunctive treatment, the serum HCG decreased within normal range. During the two-year-long follow-up, no radiological （MRI） evidence was found to suggest recurrence in MR imaging, and the serum HCG was normal in one patient, but mildly elevated in the other. HCG measurement can be crucial to the diagnosis and post-treatment monitoring of choriocarcinoma, and radical surgical tumor removal and combined modality therapy including chemotherapy and radiotherapy may ensure good results.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2007年第8期1193-1195,共3页
Journal of Southern Medical University
基金
广东省医学科学基金(A2007391)
关键词
绒毛膜癌
松果体区
病例报告
choriocarcinoma
pinealregion
case reports
