摘要
对于开放性骨折I期或延迟闭合创口所伴随的感染或骨不愈合的发生率，三项有关的回顾性群组研究得出的结果并不一致。一项有关胫骨开放性骨折的研究表明，Ⅱ期延迟闭合创口与I期闭合相比较，其骨不愈合及感染的发生率均显著降低；但此结果与另外两项研究结果迥异。而且由于各项研究中的骨折类型和固定方法均不尽相同，要对三项研究做一综合性比较亦非常困难。
There is conflicting evidence from three retrospective cohort studies regarding infection and nonunion rates when comparing primary with delayed wound closure in open fractures. One study of open tibial fractures suggests that delayed, secondary closure may result in a significant decrease in nonunion and infections compared with primary closure. These findings were not replicated in two other studies, however. Comparisons across studies were difficult as different types of fractures and fixation methods were included in each study. In addition, distribution of fracture types and fixation methods may have differed between primary and delayed closure groups. Methodologically rigorous comparative studies which control for confounding factors （eg, injury severity, fracture type and grade, fixation method） are needed to determine whether there are real differences in outcomes between primary and delayed wound closure.
出处
《中华创伤骨科杂志》
CAS
CSCD
2007年第8期776-781,共6页
Chinese Journal of Orthopaedic Trauma
