摘要
目的采用24h动态血压监测观察培哚普利/吲达帕胺复方片(Biprel)治疗老年轻、中度原发性高血压患者的临床疗效和安全性。方法129例老年轻、中度高血压患者,随机分为治疗组和对照组,治疗组应用Biprel;对照组应用非洛地平。每1～2周测量坐位血压1次,共8周,采用24h动态血压监测评价治疗8周后两组患者动态血压变化,并分别测量治疗前后两组患者的空腹血糖,血脂,血尿酸,血肌酐,血钾、钠和氯。结果治疗8周后,与治疗前相比,两组患者收缩压、舒张压、全天、日间、夜间的24h动态平均血压均明显降低(P<0.01),但组间相比差异无显著性意义(P>0.05)。Biprel对收缩压和舒张压的谷/峰比值(T/P比值)分别为81.5%和83.4%,降压平滑指数(SI)为4.52/4.83。对照组收缩压和舒张压的T/P比值为65.9%和77.6%,SI为4.17/4.47。两组治疗前后空腹血糖、血脂、血尿酸、血肌酐、血钾、钠和氯无统计学差异。结论Biprel能够持续、平稳、有效地降低老年高血压患者的24h血压,且安全性良好。
Objective： To investigate the efficacy and safety of perindopril/indapamide （Biprel） elderly patients with mild to moderate essential hypertension.Methods： 129 elderly patients with mild to moderate essential hypertension were divided randomly into group Biprel and group felodipine. Sitting blood pressure was measured by the every 1-2 weeks, after 8 weeks, clinic systolic and diastolic blood pressure measurements and anabulatory blood pressure monitoring （ABPM） were performed at the end of placebo ran-in period and at 8 weeks . Fasting blood glucose, blood lipid, blood creatinine , uric acid, blood potassium,blood natrium and blood chlorine were examined before and after 8 weeks treatment. Results： Comparing with before treatment, clinic systolic and diastolic blood pressure, the 24-hottr mean , daytime and nocturnal blood pressure in both groups decreased significantly , but not difference between two groups. The trough ： peak ratio for SBP and DBP were 81.5% and 83.4% with Biprel and 65.9% and 77.6% with felodipine. The smoothness index （SI） for SBP and DBP were 4.52and 4.83 with Biprel and 4.17and 4.47 with felodipine. The levels of blood glucose, blood lipid, blood creatinine , uric acid, blood potassium didn＇t change after treatment in two groups. Conclusion： Biprel can effectively reduce the 24hours blood pressure in elderly patients with mild to moderate essential hypertension.
出处
《井冈山医专学报》
2007年第5期11-13,共3页
Journal of Jinggangshan Medical College
