摘要
目的探讨可预测肝型肝豆状棱变性(WD)治疗效果及预后的相关因素,为临床诊断、治疗评估提供科学依据。方法根据预后将肝型患者分为肝A(好转)、肝B(恶化或死亡)2组,分析101例患者的临床表现及辅助检查结果与预后的相关性。结果单因素分析结果显示肝型WD患者的年龄、临床类型、血色素、丙氨酸氨基转移酶、血清总胆红素、凝血酶原时间、胆碱酯酶水平是影响其预后的因素,而2组患者在性别、肝脏B超分型方面的差异元统计学意义;Logistic多因素回归分析结果显示血色素、血清总胆红素、凝血酶原时间是与肝型患者预后相关的独立危险因素。结论肝型WD患者的血色素、血清总胆红素、凝血酶原时间可作为判断该病的预后指标。
Objective To find out the valuable related factors that can predict the prognosis of Wilson disease（WD） so to provide the scientific basis for the clinical diagnosis and treatment. Methods 101 WD patients with liver type were divided respectively into two groups： group A（ got better） and group B （got worse or death） according to its prognosis, and were explored to retrospectively analyze the relationship between clinical performance and the prognosis. Results Age, clinical type, the level of Hemoglobin, serum total Bilirubin, Prothrombin time and Cholinesterase were valuable prognostic factors. Sex and liver ultrasound type were not significantly different between two groups. The level of Hemoglobin, serum total Bilirubin and Prothrombin time were independent factors to the prognosis by Logistic regression analysis. Conclusion The level of Hemoglobin, serum total Bilirubin and Prothrombin time can be taken as prognostic factors in WD patients with liver type.
出处
《中国医药》
2007年第10期593-595,共3页
China Medicine
