摘要
目的了解学龄前儿童发生先天性心脏病的危险因素,从而为预防或减少先心病发生提供科学依据。方法选择2000年1月～2007年6月在无锡市第一人民医院和无锡市儿童医院确诊的先心病患儿共150例,为病例组,采用成组匹配设计。对照组选择同一时期在无锡市儿童医院非心内科住院、门诊儿童及随机抽取某一幼儿园所有学龄前阶段的幼儿,以询问和查阅病历相结合的方式予以调查,并对资料进行成组资料未分层分析和多因素非条件Logistic回归分析。结果多因素分析显示母亲月经周期(OR=1.182,95%CI:1.028～1.358)、母亲既往流产史(OR=2.795,95%CI:1.087～7.192)、孕早期的先兆流产(OR=9.070,95%CI:2.679～30.709)、孕期服药(OR=10.782,95%CI:3.174～36.624)、早期患普通感冒(OR=23.662,95%CI:1.983～282.424)及孕期非绿叶蔬菜摄入频率(OR=1.679,95%CI:1.057～2.720)均是发生先心病的危险因素。结论应广泛开展孕前父母亲健康育儿教育,在孕早期积极防治感染、谨慎用药,注意营养摄入,以减少先心病的发生。
Objective To explore the risk factors of congenital heart disease in preschool children and provide scientific evidence to prevent the disease. Methods A matched case control study was conducted in Wuxi No. 1 People＇ s Hospital and Wuxi Children Hospital from January 2000 to June 2007. Children aged 0 to 7 years diagnosed as congenital heart disease were selected as study group and other healthy children as control group, including all preschool children in a kindergarten. A detailed questionnaire was used to collect the information, Chi square test and Logistic regression analysis were applied to analyze the risk factors. Results Multi-variable analysis showed that menstrual cycle（ OR = 1. 182, 95% CI： 1. 028 - 1. 358）, past abortion history（ OR = 2.795, 95% CI： 1. 087 - 7. 192） of mother , threatened abortion（ OR = 9. 070, 95% CI： 2. 679 30.709） and common cold （ OR = 23. 662, 95% CI： 1. 983 - 282. 424） in early pregnancy, medicine taking （OR = 10. 782, 95% CI： 3. 174 - 36. 624） and the intake frequency of non-green vegetables （ OR = 1. 679, 95% CI： 1. 057 - 2.720）during pregnancy were all of the risk factors of congenital heart disease. Conclusion The education to parents before pregnancy should be carried out widely： pregnant women should actively prevent infection, avoid taking medicine and take more nutrients during early pregnancy to reduce congenital heart disease.
出处
《中国微循环》
北大核心
2007年第4期271-274,共4页
Journal of Chinese Microcirculation
