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冠心病患者尿激酶及其受体与冠脉病变的关系

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摘要 目的探讨不同类型冠心病患者尿激酶(u-PA)及其受体(u-PAR)与冠脉病变严重程度的关系。方法检测急性心肌梗死(AMI)组、不稳定型心绞痛(UA)组、稳定型心绞痛(SA)组和非冠心病(NCAD)组患者入组时外周血及冠脉血血浆u-PA浓度和全血中性粒细胞表面u-PAR表达率,并与冠脉造影结果作相关分析。结果4组研究对象冠脉血血浆u-PA浓度及全血中性粒细胞表面u-PAR表达率差异有显著性,AMI组明显高于UA组(P<0.001);UA组明显高于SA组(P<0.001);而SA组与NCAD组差异无显著性(P>0.05)。外周血的血浆u-PA浓度及全血中性粒细胞表面u-PAR表达率与冠脉血差异无显著性(P>0.05)。冠脉血血浆u-PA浓度及中性粒细胞表面u-PAR表达率均与冠脉造影的Jenkins评分呈正相关关系,分别为(r1=0.943,P<0.001;r2=0.814,P<0.001)。结论检测外周血血浆u-PA浓度及中性粒细胞表面u-PAR表达率可能可以预测冠脉病变的严重程度。
出处 《广东医学》 CAS CSCD 北大核心 2007年第9期1454-1456,共3页 Guangdong Medical Journal
基金 广东省科技计划项目(编号:2004B33701006)
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参考文献9

  • 1GIBBONS R J,CHATTERJEE K,DALEY J,et al.ACC/AHA/ACP-ASIM Guidelines for the Management of Patients With Chronic Stable Angina:Executive Summary and Recommendations[J].Circulation,2002,99:2 829 -2 848.
  • 2ACC/AHA.Guidelines for the management of patients with unstable angina and non -ST-segment elevation myocardial infarction:a report of the American college of cardiology/American heart association task force on practice guidance(Committee on the management of patients with unstable angina)[J].J Am Coll Cardiol,2002,40:1 366-1 374.
  • 3ANTMAN E M,ANBE D T,ARMSTRONG P W,et al.ACC/AHA Guidelines for the management of patients with ST-elevation myocardial infarction:A report of the American College of Cardiology/American Heart Association Task Force on Practice(Committee to Revise the 1999 Guidelines for the Management of patients with acute myocardial infarction)[J].Am Coll Cartdiol,2004,44(3):E1-E211.
  • 4JENKINS P J,HARPER R W,NESTEL P J.Severity of coronary atherosclerosis related to lipoprotein concentrateion[J].British Medical J,1978,2:388 -391.
  • 5KANSE S M,BENZAKOUR O,KANTHOU C,et al.Induction of vascular SMC proliferation by urokinase indicates a novel mechanismof action in vasoproliferative disorders[J].Arterioscler Thromb Vasc Bio,1997,17:2 848 -2 854.
  • 6PIALLAT M L B,GABBIANI G,PEPPER M S,et al.Plasminogen activator expression in rat arterial smooth muscle cells depends on their phenotype and is modulated by cytokines[J].Circ Res,1998,82:1 086 -1 093.
  • 7ANDREAS E M,ROLAND S,SCHMIDT M K,et al.Urokinase receptor surface expression regulates monocyte adhesion in acute myocardial infarction[J].Blood,2002,100:3 611 -3 617.
  • 8SCHNEIDERJ,POLLAN M,TEJERINA A,et al.Accumulation of uPA-PAI-1 complexes inside the tumour cells is associated with axillary nodal invasion in progesterone -receptor-positive early breast cancer[J].Br J Cancer,2003,88(1):96-101.
  • 9BRADLEY H S,HERBERT K L,KIMBERLEY A B,et al.Plasma urokinase antigen and plasminogen activator inhibitor-1 antigen level predict angiographic coronary restenosis[J].Circulation,1999,100:1 616-1 622.

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