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COX-2在恶性肿瘤血管生成中作用机制的研究进展 被引量：3

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摘要 研究表明,前列腺素合成限速酶环氧合酶-2(cyclooxygenase-2,COX-2),在肿瘤的发生发展中有重要作用,其可刺激上皮细胞增生,抑制肿瘤细胞凋亡,促进肿瘤血管生成,增强肿瘤细胞侵袭力,介导机体免疫抑制和突变,而其中血管生成与恶性肿瘤生长、侵袭和转移有密切关系,是目前国内外恶性肿瘤生物学及治疗学领域研究的热点和难点。笔者就近两年来对环氧合酶-2在恶性肿瘤血管生成中作用机制的新研究进展和其抑制剂的临床应用的国外研究状况作一介绍。
作者 卢长伟 董家鸿
机构地区 第三军医大学西南医院全军肝胆外科研究所-解放军西南肝胆外科医院
出处 《军医进修学院学报》 CAS 北大核心 2007年第4期310-311,共2页 Academic Journal of Pla Postgraduate Medical School
关键词 环氧水解酶类 肿瘤
分类号 R575 [医药卫生—消化系统]
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参考文献10

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同被引文献54

  • 1杨学森,龚茜芬,张广斌,余争平,余晓东.电磁辐射对大鼠海马MAPK信号通路的影响[J].中国公共卫生,2005,21(6):693-695. 被引量：12
  • 2穆润清,贺安宁,王丽,于秉治.MAPK和MPF对小鼠受精卵有丝分裂期作用[J].中国公共卫生,2006,22(5):594-595. 被引量：7
  • 3陈静君,任宏.COX-2选择性抑制剂的抗肿瘤作用研究进展[J].中国药房,2007,18(19):1508-1509. 被引量：2
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军医进修学院学报
2007年 第4期

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