摘要
目的：观察虎杖甙（ＰＤ）对兔肠缺血再灌注损伤（ＩＲＩ）的保护作用。方法：采用兔ＩＲＩ模型与经ＰＤ处理的兔ＩＲＩ模型和正常对照组作比较。结果：ＰＤ处理组动物血压降低的程度比ＩＩＲＩ组轻，平均存活时间明显延长。再灌注后２．５小时，ＰＤ处理组动物红细胞压积的升高程度明显低于ＩＩＲＩ组；ＰＤ还可以防止小肠壁和粘膜重量减轻，使其中丙二醛含量升高程度降低。结论：ＰＤ可减轻肠缺血再灌注时肠道的损害和血液浓缩，进而防止血压降低，延长动物的平均存活时间。
Objective:To investigate the preventive effect of polydation on intestinal ischemiareperfusion injury( IIRI ) in rabbits.Methods:Animals were subjected to IIRI ,and divided into polydatin(PD) treated and control groups.Results:PD evidently alleviated hypotension after intestinal ischemiareperfusion and prolonged the survival time to 11 5±4 8 hr compared with 3 5±2 4 hr in IIRI group.PD prevented the increase in hematocrit and decrease in the weight of both segmental intestine and its mucosa 2 5 hr after reperfusion.Compared with untreated group,PD group had a lower level of malondialdehyde in intestine and its mucosa.Conclusions:These data suggest that polydatin can inhibit lipid peroxidation,pervent hemoconcentration and prolong the survial time in rabbits following IIRI.
出处
《中国危重病急救医学》
CAS
CSCD
1997年第3期136-138,共3页
Chinese Critical Care Medicine
基金
广东省青年科研基金
关键词
虎杖甙
缺血
再灌注损伤
肠缺血
polydatin
intestinal ischemiareperfusion injury
