摘要
目的探讨病毒性心肌炎患者血清肿瘤坏死因子-α(TNF-α)、白介素-2(IL-2)、白介素-1β(IL-1β)的变化及临床意义。方法采用酶联免疫吸附试验(ELISA)法测定2004年中山大学第三附属医院及第一附属医院心脏内科45例病毒性心肌炎患者血清TNF-α、IL-2、IL-1β,并与正常对照组35名进行比较。结果病毒性心肌炎患者急性期TNF-α、IL-2、IL-1β明显高于恢复期及正常对照组(P<0.01);病情越重,血清TNF-α、IL-2、IL-1β越高;并与磷酸肌酸激酶同工酶(CK-MB),乳酸脱氢酶同工酶(LDH1)呈明显的正相关;恢复期血清TNF-α、IL-2、IL-1β与正常对照组比较差异无显著性意义(P>0.05)。结论病毒性心肌炎患者存在细胞免疫功能紊乱,TNF-α、IL-2、IL-1β增高可能与其发生、发展有关,并可作为病情判断及疗效的观察指标。
Objective To investigate the changes of TNF-α, IL-2 and IL-1β level in serum of patients with viral myocarditis and its clinical meaning. Methods The level of serum TNF-α, IL-2 and IL-1 β in 45 cases of viral myoearditis was detected by ELISA,and the data were compared with control group, Results Serum TNF-α,IL-2 and IL-Iβ levels in viral myocarditis patients were significantly higher than control group and related to severity of the disease. Conclusion It suggests that immune dysfunction exists in patients with viral myocarditis. Higher level of TNF-α, IL-2 and IL-β may be associated with development of the viral myocarditis,and it can be a new indicator for viral myocarditis.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2007年第5期363-364,共2页
Chinese Journal of Practical Internal Medicine
