摘要
目的了解中国主要地区临床分离葡萄球菌属对各类抗菌药物的耐药性。方法联合中国8所综合性医院,按统一方案、采用统一的材料、方法(Kirby-Bauer)和判断标准(CLSI2005年版)进行葡萄球菌属的耐药性监测。结果3577株葡萄球菌属临床分离株中,金葡菌占58.0%;凝固酶阴性葡萄球菌(CNS)占42.0%。CNS中主要有表皮葡萄球菌(27.8%),溶血性葡萄球菌(26.9%)和人型葡萄球菌(9.3%)等。金葡菌和CNS中耐甲氧西林株分别占69.5%(51.6%～93.2%)和81.4%(74.4%～93.3%)。未发现万古霉素不敏感株(VISA和VRSA)。不同地区、不同医院葡萄球菌属的耐药性各具特点。对同一种药物的耐药率有很大差异。结论在全国范围内按统一方案、同一方法和判断标准,进行细菌耐药性监测,所得结果对了解细菌耐药性变迁和指导临床用药有很大参考价值。
Objective To investigate the antibiotic resistance in clinical isolates of Staphylococcus spp. collected from different geographical regions of China in 2005. Methods Eight representative general hospitals were included in this program. Susceptibility testing was carried out by means of a unified protocol using Kirby-Bauer method. Results were analyzed according to CLSI 2005 breakpoints. Results Of the 3 577 clinical isolates of Staphylococcus, 58.0% were S. aureus and 42.0% were coagulase negative Staphylococcus （CNS）. The major CNS included S. epiderrnidis（27. 8%）, S. haemolyticus（26.9%） and S. hominis（9. 30%）. The prevalence of methicillin-resistant Staphylococcus was 69. 5% （51.6%-93.3%） in S. aureus and 81.4% （ 77. 8%-92.7%） in CNS. No vancomycinnonsusceptible strain （VISA or VRSA） was found. The resistant pattern of Staphylococcus varied greatly with different regions and different hospitals. Conclusions The data based on a nationwide resistance surveillance system with unified protocol are most important and valuable for understanding the changing resistance pattern and guiding rational antimicrobial therapy.
出处
《中国感染与化疗杂志》
CAS
2007年第4期269-273,共5页
Chinese Journal of Infection and Chemotherapy
关键词
葡萄球菌
细菌耐药性监测
抗菌药
药敏试验
Staphylococcus
Antimicrobial resistance surveillance
Antimicrobial agent
Susceptibility testing
