摘要
目的探讨合并不同内科疾病的卒中后抑郁发病率及临床特点。评价西酞普兰治疗卒中后抑郁的疗效及安全性、耐受性。方法选择2002年1月至2004年6月期间神经内科病房脑卒中患者226例,将226例病人按照合并的内科疾病的不同分为4组。根据汉密尔顿抑郁量表(HAMD)评分筛选卒中后抑郁病人。将筛选出的76例卒中后抑郁病人随机分为2组:西酞普兰治疗组38例,谷维素对照组38例,分别给予西酞普兰和谷维素治疗8周。结合HAMD、神经功能缺损评分(SNFD)及Barthel(BI)指数判定疗效。结果合并内科疾病组与不合并内科疾病组抑郁发生率有显著性差异(P<0.05)。西酞普兰治疗组前后HAMD变化值与神经功能缺损评分变化值及BI变化值之间呈正相关。结论合并内科疾病的卒中病人抑郁发生率高于不合并内科疾病的卒中病人,合并的内科疾病数目越多,卒中后抑郁的发生率越高。西酞普兰能减轻卒中后抑郁患者的神经功能缺损症状,降低残疾水平。
OBJECTIVE To investigate the morbidity and clinical features of PSD （post-stroke depression） patients and observe the effect of internal disease on the onset and prognosis of PSD patients. To evaluate the efficacy of citalopram in these patients through a controlled clinical trial. METHODS 226 patients with stroke who fulfilled the criteria of our study were enrolled and were divided into four groups according to different internal disease they complicated with. All patients were tested with HAMD and 76 patients were selected out.Thoses patients were divided into treat group （38 examples） and contrast group （38 examples） at random and treated separately with citalopram and oryzanol.In each group, HAMD, the scores of nervous functional deficiency and Barthel index were performed before ＂and after drug therapy under the same condition, the clinical outcome was measured. RESULTS There was marked differential betwee the internal disease group and no internal disease group （P〈0.05）. There was evident differential between the scores of nervous functional deficiency or Barthel index of pretreatment and that of post treatment in treatment group and the variation was different between both groups. CONCLUSIONS The morbidity of PSD in group with internal disease is higher than the group without internal disease.Neverthless, it has no relationship with the type of the internal disease, but has positive relationship with the number of the internal disease.Citalopram can improve the depression symptom and the tolerability of citalopram is excellent.Citaloprom can lessen the neurological sympton of PSD patients and decrease the level of deformity.
出处
《中国初级卫生保健》
2007年第8期52-54,共3页
Chinese Primary Health Care
