摘要
目的:探讨dl-3-正丁基苯酞软胶囊(恩必普软胶囊)治疗慢性脑供血不足的临床疗效及对慢性脑供血不足病人认知功能改善的影响。方法:将60例慢性脑供血不足病人随机分为治疗组和对照组,每组30例,治疗组口服dl-3-正丁基苯酞软胶囊,每次200毫克,每日3次;对照组口服复方丹参片,每次4片,每日3次,疗程为8周,治疗前后进行疗效评价和P300数据采样,同时给予同步MMSE、HDS量表评分。结果:治疗组总有效率为70%,对照组总有效率为53.3%,2组治疗后比较差异有显著意义(P<0.05);治疗组治疗前、后MMSE和HDS量表得分情况比较,均有明显改善(P<0.01),与对照组治疗后比较差异有显著意义(P<0.05);治疗组治疗前、后P300波潜伏期及P300波幅差异均有显著意义(P<0.05),与对照组治疗后比较均有显著差异(P<0.05)。结论:dl-3-正丁基苯酞软胶囊对慢性脑供血不足病人安全有效。
Objective： To observe the therapeutic effect of Dl-3-budylphthalinde on chronic cerebral circulation insufficiency （CCCI） and the effects of Dl-3-budylphthalinde on cognitive function in CCCI. Methods： 60 patients with CCCI were randomly divided into treatment group and control group. 30 patients in treatment group were treaded with Dl-3-budylphthalinde 200 mg once ,3 times a day; the other 30 patients in control group were treaded with Fufangdanshen tablet 4 tablets once ,3 times a day, with a treatment course of 8 weeks for both groups. The therapeutic effect was measured with Event-related potential P300, MMSE and HDS. Results： The total effective rates of Dl-3-budylphthalinde and Fu- fangdanshen tablet were 70% and 53.3% respectively（P〈0.05）. The scores of MMSE and HDS in treatment group were improved obviously after treatment（P〈0.01 ）, there was a significant difference between two groups （P〈 0.05）;After treatment ,the latency of P300 reduced and the amplitude of P300 hoisted compared with before treatment in treatment group（P〈0.05）, there was a significant difference between two groups （P 〈 0.05）. Conclusion： Dl-3-budylphthalinde should be regarded as an effective and safe medication in treating CCCI.
出处
《脑与神经疾病杂志》
2007年第4期260-262,共3页
Journal of Brain and Nervous Diseases
基金
河北省科技攻关计划项目072761285
