基因标记物与子宫内膜癌相关性研究进展
摘要
肿瘤的发生是多基因、多步骤的复杂过程,癌基因的激活、抑癌基因的失活、细胞周期调节紊乱及细胞异常增殖均可导致正常子宫内膜细胞的恶性转化及子宫内膜癌的发生发展。选取具有代表性基因标记物——凋亡抑制基因(survivin)、抑癌基因(PTEN)、增殖细胞核抗原(PCNA),综述三者在子宫内膜细胞癌变过程中的作用及其相关性。
出处
《国外医学(妇产科学分册)》
2007年第4期244-246,共3页
Foreign Medical Sciences(Obstet Gynecol Fascicle)
参考文献20
-
1Covens A, Brunetto VL, Markman M, et al. Phase Ⅱ trial of danazol in advanced, recurrent, or persistent endometrial cancer: a Gynecol Oncol Group study [ J ]. Gynecol Oncol, 2003, 89(3) : 470-474.
-
2Erkanli S, Bolat F, Kayaselcuk F, et al. COX-2 and survivin are overexpressed and positively correlated in endometrial carcinoma [J]. Gynecol Oncol, 2007, 104(2):320-325.
-
3Ghosh JC, Dohi T, Raskett CM, et al. Activated checkpoint kinase 2 provides a survival signal for tumor cells[J]. Cancer Res, 2006, 66 (24): 11576-11579.
-
4Lens SM, Vader G, Medema RH. The case for Survivin as mitotic regulator[j]. Curt Opin Cell Biol, 2006, 15(6): 616-622.
-
5Takai N, Miyazaki T, Nishida M, et al. Survivin expression correlates with clinical stage, histological grade, invasive behavior and survival rate in endometrial carcinoma[J]. Cancer Lett, 2002, 184 (1) : 105- 116.
-
6Lehner R, Enomoto T, McGregor JA, et al. Correlation of survivin mRNA detection with histologic diagnosis in nomal endometrium and endometrial carcinoma[J]. Acta Obstet Gynecol Scand, 2002, 81(2) : 162-167.
-
7Downes CP, Perera N, Ross S, et al. Substrate specificity and acute regulation of the turnout suppressor phosphatase, PTEN [ J ]. Biochem Soc Symp, 2007, 74(1): 69-80.
-
8Konopka B, Janiec-Jankowska A, Czapczak D, et al. Molecular genetic defects in endometrial carcinomas: microsatellite instability, PTEN and beta-catenin (CTNNB1) genes mutations [J]. J Cancer Res Clin Oncol, 2007, 133(6): 361-371.
-
9Kanamofi Y, Kigawa J, Itamochi H, et al. PTEN expression is associated with prognosis for patients with advanced endometrial carcinoma undergoing postoperative chemotherapy [J]. Int J Cancer, 2002, 100(6): 686-689.
-
10Shen WH, Balajee AS, Wang J, et al. Essential Role for Nuclear PTEN in Maintaining Chromosomal Integrity [J]. Cell, 2007, 125 (1): 157-170.
-
1白守民,梁碧玲,崔念基.基因标记物在头颈部肿瘤中的应用[J].国外医学(肿瘤学分册),2001,28(3):207-209.
-
2袁晓奕,杨为民.膀胱肿瘤标记物研究进展[J].现代泌尿外科杂志,2002,7(3):181-183. 被引量:2
-
3张志勇,浦佩玉,康春生,裘明哲,王广秀,贾志凡,江荣才.人脑胶质瘤中β-catenin的表达与细胞增殖相关性研究[J].中国临床神经科学,2006,14(1):11-14. 被引量:1
-
4周瑞娟,陈红风.中药影响乳腺癌细胞周期的研究进展[J].肿瘤防治研究,2012,39(1):100-104. 被引量:8
-
5张勇,王斌,周幽心.Gsk-3β β-catenin CyclinD1在脑胶质瘤中的表达及意义[J].基层医学论坛,2014,18(1):14-16. 被引量:1
-
6李再波,解正新,张和平,赵澄泉.子宫内膜细胞在巴氏宫颈细胞学检查中的临床意义和处理[J].中华病理学杂志,2013,42(10):708-711. 被引量:7
-
7李韬,赵金伟,葛巨刚,李晨玉.外周血基因标记物mRNA表达与老年癌性肠梗阻肝转移的相关性[J].中国老年学杂志,2013,33(13):3020-3021.
-
8孙丹丹,王颖梅,张慧英,赵敬,马学功,薛凤霞.子宫内膜癌雄激素受体表达及临床意义[J].实用妇产科杂志,2012,28(2):131-134. 被引量:8
-
9康德新,栾文勃,陈志奇,张磊,梁春林,张国利.胰腺癌肿瘤基因标记物的研究现况[J].山东医药,2012,52(4):104-105. 被引量:1
-
10梁锐,王芳,杨耘.大肠癌的基因标记物及其遗传学改变[J].实用癌症杂志,2004,19(2):218-220. 被引量:2