摘要
目的:通过测定穿心莲内酯和脱水穿心莲内酯的含量来控制清火栀麦片的质量。方法:用梯度洗脱法测定清火栀麦片中穿心莲内酯和脱水穿心莲内酯的含量。结果:加样回收率穿心莲内酯为98.9%,RSD为1.1%;脱水穿心莲内酯为99.3%,RSD为0.9%,方法的重现性好。结论:所建立的方法可准确、快速地进行定量检测,可有效的控制该制剂的质量。
OBJECTIVE To control the quality of Qinghuo Zhimai tablets by determine the content of andrographolide and chrysophanol dehydroandrographolide. METHODS Gradient elution method was used to determine the content of andrographolide and dehydroandrographolide in Qinghuo Zhimai tablets. RESULTS The recovery of andrographolide was 98. 9% with RSD of 1.1%, the recovery of dehydroandrographolide was 99. 3% and RSD was 0. 9%. CONCLUSION The established method is accurate and rapid for the determination. It can be used for quality control of Qinghuo Zhimai tablets effectively.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2007年第8期1068-1070,共3页
Chinese Journal of Hospital Pharmacy
关键词
清火栀麦片
梯度洗脱
穿心莲内酯
脱水穿心莲内酯
Qinghuo Zhimai tablets
gradient elution method
andrographolide
dehydroandrographolide
