摘要
目的检测子痫前期-子痫患者肝功能指标尤其是血浆中纤维连接蛋白(FN)的变化,探讨子痫前期-子痫患者肝脏损伤的情况及FN在其改变中的作用。方法以59例子痫前期-子痫患者作为研究对象,分为轻度子痫前期及重度子痫前期/子痫两组,选择正常非妊娠妇女22例及正常孕晚期妇女35例作为对照组,检测各组妇女血浆中FN、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总蛋白(TP)、白蛋白(ALB)、碱性磷酸酶(ALP)、总胆红素(TBIL),直接胆红素(DBIL)进行统计学分析。结果FN:子痫前期-子痫组较正常非孕组升高(P<0.05),较正常孕晚期升高(P<0.01);轻度子痫前期组较正常孕晚期升高(P<0.05),与正常非孕组差异无统计学意义(P>0.05);重度子痫前期/子痫组较正常非孕组及正常孕晚期组增高(P<0.01),较轻度子痫前期升高,差异有统计学意义(P<0.05)。肝功:ALT、AST:子痫前期-子痫组较正常孕晚期升高(P<0.05);重度子痫前期/子痫组较正常非孕组及正常孕晚期组增高(P<0.01)。TP、ALB:正常孕晚期较正常非孕组降低(P<0.01);子痫前期-子痫组较正常非孕组及正常孕晚期降低(P<0.01);轻度子痫前期及重度子痫前期/子痫组均较正常非孕组及正常孕晚期降低,差异有统计学意义。ALP:正常孕晚期、子痫前期-子痫组、轻度子痫前期及重度子痫前期/子痫组较正常非孕组升高(P<0.01);子痫前期-子痫各组与正常孕晚期组比较,差异无统计学意义(P>0.05)。TBIL、DBIL:未见明显变化。重度子痫前期/子痫组与轻度子痫前期组ALT、TP比较,差异有统计学意义(P<0.01),AST比较,差异有统计学意义(P<0.05)。结论随着病情的发展,子痫前期-子痫患者出现了不同程度的肝脏损伤;FN既可作为肝脏损伤的重要指标之一,又可能提示在肝脏损伤及修复过程中可能起到一定的作用。
Objective To investigate the changes of plasma fibronecfin（FN） and the liver function in the patients of preeclampsia- eclampsia. Methods FN,ALT,ASr,TP, ALB,ALP,TBIL,DBIL were examined in 59 patients with precclampsia-eclampsia divided into mild pre-eclampsia and severe preeclampsia-eclampsia, comparing with 35 normal late-pregnancy woInen,22 non- pregnancy women. Results FN： The FN in patients with preeclampsia-eclampsia is higher than non-pregnancy women（ P 〈 0.05） and normal late-pregnancy women（ P 〈 0.01）;FN in mild preeclampsia is higher than normal late-pregnancy women（ P 〈 0.05） ; FN in severe preeclampsia-eclampsia is higher than non-pregnancy women and normal late-pregnancy women（ P 〈 0.01 ）, the same to comparing with mild preeclampsia（ P 〈 0.05）. ALT, AST： preeclampsia-eclampsia is higher than normal late-pregnancy women（ P 〈 0.05）;TP, ALB： normal late-pregnancy women is lower than non-pregnancy women（ P 〈 0.01） ; preeclampsia-eclampsia is lower than non-preg- nancy women and normal late-pregnancy women（ P 〈 0.01）; ALP： normal late-pregnancy women,preeclampsia-eclampsia,mild pre- eclampsia, severe preeclampsia-eclampsia are higher than non-pregnancy women; Changes between each group of preeclampsia- eclampsia and normal late-pregnancy women have no statistical significance（ P 〉 0.05）. The ALT and TP in severe preeclampsia- eclampsia has statistical changes comparing with mile preeclampsia（ P 〈 0.01 ）,the same to AST（ P 〈 0.05）. Conclusion With the development of preeclampsia-eclampsia , the patients have liver disfuncfion. FN can be one of makes to examine the liver disfuntion and appears to be useful in the injury and reconditioning of liver.
出处
《中国实验诊断学》
2007年第8期1038-1040,共3页
Chinese Journal of Laboratory Diagnosis
