摘要
目的:比较国产与进口头孢吡肟注射剂治疗泌尿系感染的疗效、不良反应及成本。方法:用随机、平行、对照、多中心单盲试验设计(几个不同地区的医院病例研究,且受试者不知情),以进口头孢吡肟注射剂作对照组。进入疗效分析病例数为122例,其中国产试剂组61例,对照组61例。两组病例均为每次给药2g,60分种内静滴,1日2次,疗程7至14天。运用药物经济学的最小成本分析法进行经济学评价。结果:国产与进口头孢吡肟注射剂治疗泌尿系感染的临床有效率、致病菌清除率、不良反应发生率差异无统计学意义。但国产头孢吡肟组的成本比进口组低18.9%。结论:国产头孢吡肟注射剂与进口头孢吡肟注射剂相比,疗效相当,价格更便宜。
OBJECTIVE ： To evaluate the clinical efficacy, ADRs, and costs of domestic vs. imported cefepime injections in the treatment of urinary infection. METHODS： A randomized, parallel controlled, multicenter, single blind trial was conducted in patients with urinary tract infection in several hospitals （with subjects not knowing the fact） with import cefepime injections as control. A total of 122 cases were included in our analysis of curative effects： the subjects in the trial group （n= 61） were assigned to receive 2g cefepime domestic cefepime injection and the control group （n = 61） were to receive 2g imported cefepime injection by intravenous drip within 60min bid for 7 - 14 days. A cost - minimization analysis was conducted for the pharmacoeconomic evaluation. RESULTS： There were no significant differences in clinical effective rate, clearance rate of bacterias, incidences of ADRs between the two groups, but the cost of domestic cefepime was 18.9 % lower than the imported one. CONCLUSION： The domestic cefepime injection is equivalent to its imported counterpart in efficacy, but is cheaper.
出处
《中国医院用药评价与分析》
2007年第4期295-297,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
头孢吡肟注射剂
泌尿系感染
最小成本分析
Cefepime injection
Urinary infection
Cost - minimization analysis
