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阿维A对寻常型银屑病患者血清MMP-2及TIMP-2的影响 被引量：3

The effect of acitretin on serum MMP-2 and TIMP-2 in the patients with psoriasis vulgaris
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摘要 目的:确定基质金属蛋白酶-2(MMP-2)及金属蛋白酶组织抑制剂-2(TIMP-2)在寻常型银屑病发病中的作用及阿维A对其的调节作用。方法:应用双抗体夹心酶联免疫吸附法(ELISA)检测30例寻常型银屑病患者经阿维A治疗前后外周血清中MMP-2及TIMP-2的水平。结果:寻常型银屑病患者血清中MMP-2、TIMP-2、MMP-2/TIMP-2的水平较正常人对照组显著增高(P<0.001)。治疗后血清中MMP-2、TIMP-2、MMP-2/TIMP-2较治疗前显著下降(P<0.01)。结论:阿维A可通过降低血清MMP-2,升高TIMP-2水平而起到治疗作用。 Objective： To determine the effect of acitretin on MMP - 2 and TIMP- 2 and to explore its treatment mechanism in the patients with psoriasis vulgaris. Methods： Serum levels of MMP - 2 and TIMP - 2 were measured by double antibody sandwich enzyme - linked innnunosorbent assay （ELISA） in 30 patients with psoriasis vulgaris before and after treatment with acitretin. Results： The senml levels of MMP-2, TIMP-2 and MMP-2/TIMP-2 were significantly higher than those in normal controls （ P 〈 0. 001 ） and were significantly higher before the treatment than after treatment （ P 〈 0.01 ）. Conclusion： The results indicate that the therapeutic effect of acitretin in the treatment psoriasis vulgaris may be by inhibiting the secretion of MMP - 2 and increasing the level of TIMP - 2.
作者 罗权 林玲 朱慧兰 邓景航 何玉清 陈绍谦 张锡宝
机构地区 广州市皮肤病防治所
出处 《中国麻风皮肤病杂志》 2007年第8期661-663,共3页 China Journal of Leprosy and Skin Diseases
基金 广州市医药卫生科研项目(2005-YB-126)
关键词 阿维A 银屑病 基质金属蛋白酶 金属蛋白酶组织抑制剂 acitretin psoriasis MMP TIMP
分类号 R758.63 [医药卫生—皮肤病学与性病学]
  • 相关文献

参考文献7

  • 1Suomela S,Kariniemi AL,Snellman E,et al.Metalloelastase(MMP-12) and 92-kDa gelatinase (MMP-9) as well as their inhibitors,TIMP-1 and-3,are expressed in psoriatic lesions.Exp Dermatol 2001; 10(3):175-183.
  • 2Fleischmajer R,Kuroda K,Hazan R,et al.Basement membrane alterations in psoriasis are accompanied by epidermal overexpression of MMP-2 and its inhibitor TIMP-2.J Invest Dermatol 2000;115(5):771-777.
  • 3陈晋广,任小丽,胡雅玉,陈祥恩.银屑病皮损中MMP-2 MMP-9的检测[J].中国皮肤性病学杂志,2005,19(4):201-202. 被引量：13
  • 4Giannelli G,Erriquez R,Iannone F,et al.MMP-2,MMP-9,TIMP-1 and TIMP-2 levels in patients with rheumatoid arthritis and psoriatic arthritis.Clin Exp Rheumatol 2004;22(3):335-338.
  • 5Alenius GM,Jonsson S,Wallberg Jonsson S,et al.Matrix metalloproteinase 9 (MMP-9) in patients with psoriatic arthritis and rheumatoid arthritis.Clin Exp Rheumatol 2001; 19(6):760.
  • 6黄振明,罗权,林玲,李常兴,张锡宝.关节病性银屑病患者阿维A治疗前后血清血管内皮生长因子和金属蛋白酶-9的变化[J].临床皮肤科杂志,2005,34(9):582-583. 被引量：4
  • 7Sawa M,Tsukamoto T,Kiyoi T,et al.New strategy for antedrug application:development of metalloproteinase inhibitors as antipsoriatic drugs.J Med Chem 2002;45(4):2930-2936.

二级参考文献12

  • 1张选奋.皮肤的细胞外基质及其与银屑病的关系[J].中国皮肤性病学杂志,1996,10(2):105-106. 被引量：2
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共引文献14

同被引文献16

  • 1罗权,张锡宝,吴志华,陈绍谦.寻常型银屑病患者外周血VEGF水平的动态观测[J].中国麻风皮肤病杂志,2004,20(6):548-549. 被引量：7
  • 2张锡宝,罗权,吴志华,陈绍谦.血管内皮生长因子及其受体在银屑病发病中的作用及意义[J].中华皮肤科杂志,2005,38(3):140-142. 被引量：30
  • 3黄振明,罗权,林玲,李常兴,张锡宝.关节病性银屑病患者阿维A治疗前后血清血管内皮生长因子和金属蛋白酶-9的变化[J].临床皮肤科杂志,2005,34(9):582-583. 被引量：4
  • 4Creamer JD,Barker JN.Vascular proliferation and angiogenic factors in psoriasis.Clin Exp Dermatol 1995;20:6-9.
  • 5Dvorak HF,Brown LF,Detmar M,et al.Vascular permeability factor/vascular endothelial growth factor,microvascular hyperpermeability,and angiogenesis.Am J Pathol 1995;146(5):1029-1039.
  • 6Suomela S,Kariniemi AL,Snellman E,et al.Metalloelastase (MMP-12) and 92-kDa gelatinase (MMP-9) as well as their inhibitors,TIMP-1 and -3,are expressed in psoriatic lesions.Exp Dermatol 2001;10(3):175-183.
  • 7Bhushan M,Mclaughlin B,Weiss JB,et al.Levels of endothelial cell stimulating angiogenesis factor and vascular endothelial growth factor are elevated in psoriasis.Br J Dermatol 1999;141:1054-1060.
  • 8Zucker S,Mira H,Conner CE,et al.Vascular endothelial growth factor induce tissue factor and matrix metalloproteinase production in endothelial cells:conversion of prothrombin results in progelatinase a activation and cell proliferation.Int J Cancer 1998;75:780-786.
  • 9Creamer JD,Barker JN.Vascular proliferation and angiogenic factors in psoriasis[J].Clin Exp Dermatol,1995,20:6-9.
  • 10Suomela S,Kariniemi AL,Snellman E,et al.Metalloelastase (MMP-12) and 92-kDa gelatinase (MMP-9) as well as their inhibitors,TIMP-1 and -3,are expressed in psoriatic lesions[J].Exp Dermatol,2001,10(3):175-183.

引证文献3

二级引证文献8

中国麻风皮肤病杂志
2007年 第8期

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