摘要
目的:CD4+CD25+调节性T细胞是一群具有免疫调节或免疫抑制功能的细胞。越来越多的实验证明,CD4+CD25+调节性T细胞在维持外周免疫耐受中起重要作用,这种T细胞的数量减少或功能缺失可导致自身免疫性疾病的发生。本文就CD4+CD25+调节性T细胞及其在自身免疫性疾病中作用的研究进展做一综述。资料来源:应用计算机检索CNKI、Medline、EMCC数据库和手工检索2006-2007年的相关文献。检索词为"CD4+CD25+T调节性细胞,自身免疫病,免疫耐受,CD4+CD25+regulatory T cell,Treg,autoimmune disease,immune tolerance"。资料选择:检索范围包括临床研究(不限研究对象的年龄、性别、种族)和基础研究,不限体内和体外研究。资料提炼:共收集到相关文献675篇,选择其中33篇英文文献进行重点阅读和分析。资料综合:CD4+CD25+调节性T细胞具有免疫抑制功能,在机体的免疫调节中发挥重要作用。与其免疫调节功能相关的杀伤性T细胞淋巴细胞相关抗原4、CD45RO、糖皮质激素诱导的肿瘤坏死因子受体、淋巴细胞的无能相关基因等细胞表面分子和白细胞介素2、白细胞介素10、白细胞介素4、转化生长因子β等细胞因子的研究不断深入。此外,CD4+CD25+调节性T细胞功能的发挥还与FOXP3的表达密切相关。CD4+CD25+调节性T细胞数量的减少、抑制功能的受损和(或)细胞表面分子表达的缺陷可能导致1型糖尿病、多发性硬化和炎症性肠病等多种自身免疫病的发生。结论:CD4+CD25+调节性T细胞主要通过细胞接触依赖机制和抑制性细胞因子依赖机制发挥免疫抑制效应。其数量的减少、功能的受损和(或)表面分子表达的缺陷与自身免疫病的发生发展密切相关。
OBJECTIVE： CD4^＋CD25^＋ regulatory T cell is a crowd of cells, which can regulate and suppress the immune response. More and more experiments have proved that CD4^＋CD25^＋ regulatory T cells play an important role in the maintenance of peripheral immune tolerance, and the decrease or afunction of them will result in the development of autoimmune disease. This article is a review about the research development on CD4^＋CD25^＋ regulatory T cell and its role in the autoimmune disease. DATA SOURCES： CNKI, Medline, EMCC and papers published in major journals were undertaken to identify the relevant articles from 2006 to 2007 with the key words of ＂CD4^＋CD25^＋ regulatory T cell,autoimmune disease,immune tolerance＂ in English and in Chinese. STUDY SELECTION： The check included clinical research （no matter age, sex or nation） and basic research, no matter in vitro and in vivo. DATA EXTRACTION： Totally 675 relevant articles were collected and 33 English papers of them were carefully read and analyzed. DATA SYNTHESIS： CD4^＋CD25^＋ regulatory T cells suppress immune response, and play a very important role in the regulation of immune response. More and more research are focus on the cell surface molecule such as CTLA-4, CD45RO, glucocorticoid-induced tumor necrosis factor receptor （GITR） and GRAIL and cytokines interleukin （IL）-2, 11_-10, IL-4 and transforming growth factor （TGF）-13, which are related to immunological regulation. In addition, the function of CD4^＋CD25^＋ regulatory T cell has a close correlation with FOXP3. The decrease of CD4^＋CD25^＋ regulatory T cell, damage of their suppressive function and （or） defect of the expression of cell surface molecule will result in a development of many kinds of autoimmune disease, such as Type 1 diabetes mellitus （T1DM）, multiple sclerosis（MS） and inflammatory bowel disease （IBD）. CONCLUSION： CD4^＋CD25^＋ regulatory T cells suppress the immune response by cell-cell contact depended mechanism and suppressive cytokine depended mechanism. The decrease of the CD4^＋CD25^＋ regulatory T cell, damage of their suppressive function and （or） defect of the expression of cell surface molecule has a close correlation with the development of autoimmune disease.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2007年第33期6676-6680,共5页
Journal of Clinical Rehabilitative Tissue Engineering Research
