摘要
目的评价α硫辛酸治疗糖尿病周围神经病变的疗效及是否能改善神经传导速度。方法选择2型糖尿病伴有不同程度周围神经病变患者58例,随机分为两组,应用胰岛素控制血糖在较满意水平,治疗组选用α硫辛酸(商品名奥力宝)600mg/日静脉滴注,对照组选用甲钴胺(商品名弥可保)1000μg/日静脉滴注,疗程为14天。结果治疗组治疗后对临床症状的改善明显优于对照组,治疗组治疗前后正中神经,尺神经,腓总神经,胫神经的运动神经传导速度与感觉神经传导速度总体无明显改善。结论采用α硫辛酸治疗糖尿病周围神经病变能明显改善临床症状,但对神经传导速度无改善。
Objective To study the effects of treatment with α-lipoic acid on diabetic peripheral nerve conduction and wether it could improve the transmit speed of nerve. Methods 56Ⅱ diabetic pa- tients with diabetic peripheral neuropathy were selected and were divided into two groups randomly. The patients＇ blood glocose were controled in satisfied level by insulin. The group with treatment adopted α-lipoic acid 600mg/day. The control group adopted Mecobalamin 1000ug/day. Course of treatment was 14 days. Results The effects of treatment with α-lipoic acid on diabetic peripheral neuropathy had an advantage with the effects of treatment with Mecobalamin, α-lipoic acid had no effects on nerve conduction velocity. Conclusions α-lipoic acid could improve the clinical symptom on diabetic peripheral neuropathy,but had no effects on nerve conduction velocity.
出处
《齐齐哈尔医学院学报》
2007年第13期1544-1545,共2页
Journal of Qiqihar Medical University
