摘要
目的:研究辛伐他汀对急性冠脉综合征患者的血脂和C反应蛋白影响。方法:将60例急性冠脉综合征患者随机分为常规治疗组和辛伐他汀组,常规治疗组予阿斯匹林、肝素、硝酸酯类、血管紧张素转换酶抑制剂及β受体阻滞剂等,不使用其他调脂、抗氧化药物、非类固醇类消炎镇痛药物;辛伐他汀组在常规治疗基础上加用辛伐他汀每日20mg晚餐后服用,疗程6周,治疗前后测量血脂及C反应蛋白并与健康对照组(n=30)比较。结果:急性冠脉综合征患者C反应蛋白升高,经治疗后均有下降,辛伐他汀组TC、TG、LDL-C水平及C反应蛋白较对照组下降明显,HDL-C水平升高。两组比较有统计学差异,未见有严重不良反应出现。结论:辛伐他汀可以降低急性冠脉综合征患者的血脂及C反应蛋白水平,具有稳定斑块、抑制炎症等作用,是一有效、安全的治疗手段。
Objective To observe the influence of simvastatin on blood lipid and C- reactive protein （CRP） in patients with acute coronary syndrome （ACS）, Methods 60 patients were divided into treatment group with simvastatin and control groud without simvastatin,The treatment groud receive simvastatin 20mg/d,The blood lipid and C- reactive protein were measured before and after the treatment. 30 healthy people were measured as healthy control group. Results Patients with Acs had higher levels of CRP than those of healthy control group. After simvastatin treatment, the levels of TC, TG , LDL- C and CRP were significantly dceased. Conclusions simvastatin can reduce the levels of CRP and blood lipid evidently, has the effect of anti - inflammation and making plaque stable.
