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妊娠期糖尿病研究现状及临床早期干预意义 被引量：6

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摘要 妊娠期糖尿病(GDM)的发病与胰岛素抵抗(IR)和分泌缺陷有关。近年来有关IR的研究多集中在几个潜在的候选因子上,如脂联素,瘦素,肿瘤坏死因子(TNF-α)及血浆游离脂肪酸。脂联素水平与IR负相关,减肥可增加脂联素水平。母体血清瘦素浓度与IR呈负相关,孕早期高血浆瘦素水平,被认为对孕期GDM发病有较高预测价值。GDM具有多基因遗传易感性,TNF-α基因308G→A变异,可增加孕妇患妊娠期糖尿病的危险性。A等位基因可能通过增加TNF-α的释放参与IR,导致GDM的发病。血浆游离脂肪酸(FFA)是IR的重要调节因素,GDM孕妇FFA水平增高。目前GDM的早期预测,早期干预正在成为可能与必要。
作者 迟晓艳 王静怡
机构地区 青岛大学医学院附属青岛市市立医院妇产科
出处 《生殖与避孕》 CAS CSCD 北大核心 2007年第8期549-552,共4页 Reproduction and Contraception
关键词 妊娠期糖尿病(GDM) 胰岛素抵抗(IR) 胰岛B细胞分泌缺陷 早期预测 早期干预
分类号 R714.25 [医药卫生—妇产科学]
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参考文献25

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二级参考文献21

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生殖与避孕
2007年 第8期

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