摘要
尝试用高压静电成囊装置(静电喷雾法)来制备一种强度高、生物相容性好的海藻酸钙-羧甲基纤维素钠液芯微囊.在初步试验的基础上,利用正交试验的方法考察了海藻酸钠、羧甲基纤维素钠以及氯化钙的浓度对成囊过程中微胶囊膜厚、粒径等的影响.同时结合不同制备条件下微胶囊的成囊性,优化海藻酸钙-羧甲基纤维素钠微胶囊制备工艺.在优化的工艺参数中海藻酸钠、氯化钙以及羧甲基纤维素钠的质量浓度分别为10,30,15 g/L.
Electrostatic spray method is used to prepare calcium alginate-sodium carboxymethyl cellulose liquid core microcapsules with high membrane intensity and good hiocompatibility, The contrast experimental analyses on the spray voltage, pinhead size and other influencial factors are carried out. Then the orthogonal tests proceed to get the optimal parameters for liquid core microcapsules preparation considering membrane-formation properties under different preparation conditions. The optimal technological parameters are 10 g/L,30 g/L and 15 g/L of sodium alginate, sodium carboxymethyl cellulose and calcium chloride solutions respectively.
出处
《上海理工大学学报》
EI
CAS
北大核心
2007年第4期349-352,共4页
Journal of University of Shanghai For Science and Technology
基金
上海市自然科学基金资助项目(05ZR14088)
上海市科委重点项目(05JC14034)
上海市重点学科建设资助项目(T0503)
关键词
微胶囊
静电喷雾
液芯
microcapsule
electrostatic spray
liquid core
