摘要
19F的磁旋比和相对灵敏度接近质子;^(19)F NMR化学位移范围可达δ1000,谱图分辨率高;^(19)F NMR对环境因素较氢谱远为敏感、复杂,可反映出化合物结构的细微差别.由于正常生物体内含氟成分很少,干扰小,因此在生物医学研究中引入氟代物进行^(19)F NMR研究有特殊意义.对氟化物的^(19)F NMR化学位移和偶合常数的范围也分类作了总结.
Fluorine-19 (19F) isotope has 100% natural abundance, and the magnetic moment and relative NMR sensitivity of 19F nuclei are similar to those of 1H nuclei. The total range of 19F NMR chemical shifts is over δ 1 000, giving good spectral resolution. Compared to 1H NMR, 19F NMR is more sensitive to the changes in molecular structure and environmental factors, and thus can be used to probe fine structural difference of the compounds. In vivo 19F NMR spectroscopy provides a highly specific tool for identifying the existence of fluorine-containing drugs and their metabolites in the tissue. In this paper, the 19F chemical shifts and coupling constants of various fluorine-containing compounds were summarized and reviewed.
出处
《波谱学杂志》
CAS
CSCD
北大核心
2007年第3期353-364,共12页
Chinese Journal of Magnetic Resonance
基金
陕西省自然科学基金资助项目(2003B17).
