摘要
采用整群抽样方法,选择了1018名1~7岁新生儿期接种3针10μg乙型肝炎血源疫苗免疫的儿童,检测HBsAg、抗BHs和抗HBc,以评价乙肝疫苗纳入儿童计划免疫,实施低剂量免疫策略7年后的效果。结果显示HBsAg阳性率为2.0%,与1985年该免疫计划实施前儿童HBsAg阳性率12.7%比较,疫苗保护率为85.0%,保护率从免疫后1~2年的82.0%逐年上升为免疫后7年的96.4%;抗HBs阳性率为79.7%,保护性抗体阳性率为54.2%;两者从免疫后1~2年的91.8%和75.0%明显下降为免疫后第7年的73.7%和48.2%;抗HBc阳性率为3.0%,显著低于免疫前的18.4%。结果说明低剂量免疫策略控制乙肝是成功的,实施7年后是否需加强免疫有待进一步观察。
A 7 year cross sectional follow up study was conducted to evaluate the long term effectiveness of a model HB immunization integrated with EPI program (low dose strategy) in Long An County of China in 1994.A sample of 1018 children aged 1 ̄7 years,who received 3 dosage of 10μg HB vaccine in infancy starting from 1987,were selected to test HBsAg,Anti HBs and Anti HBc.Of 1018 children,HBsAg positive rate was 2.0%,and effectiveness was 85.0%,compared with 12.7% of the baseline survey in 1985.The increase of effectiveness was from 82.0% at 1 ̄2 years to 96.4% at 7 years after infancy immunization.The Anti HBs positive rate was 79.7%,and the protective anti HBs positive rate was 54.2%,and the decrases for both rates ranged from 91.8% and 75.0% at 1 ̄2 years to 73.7% and 48.2% at 7 years after first dosages vaccination.Anti HBc positive rate was 3.0%, significantly lower than 18.4% of the baseline survey.The results showed that the low dose strategy was successful,and that need for vaccination against HB was not demonstrated in Long An County at 7 year after initial immunization.
基金
美国中华医学基金
关键词
乙型肝炎
低剂量
免疫接种
远期效果
新生儿
Hepafifis B\ Long term effectiveness\ Low dose immunization integrated