摘要
研究通过添加树脂AB-8吸附转化产物以降低高浓度产物对Yarrowia lypolitica细胞的毒性,进而提高产量。确定了蓖麻油添加量25 g/L、树脂量7.5%、pH值7.5的最佳优化工艺,产物的最大比生成速率提高36%且达到最大值后降低较慢,有利于产物积累,56 h后总产量达到2.17 g/L,耦合工艺在提高产量的同时又能较好地实现产物的分离。
The product in the production of γ-decalactone by biological pathway has obvious toxicity to the growth of Yarrowia lypolitica.Resin AB-8 was added to adsorb converted product to reduce the toxicity on Yarrowia lypolitica.The optimum conditions were castor oil 25g/L, 7.5% AB-8, pH 7.5. The maximal specific γ -decalactone formation rate increased by 36% and decreased slowly after it reached a maximum, leading to better product accumulation. The total product concentration reached 2.17g/L after 56h. As a result, addition of resin not only increased the production but also separated the product.
出处
《化工进展》
EI
CAS
CSCD
北大核心
2007年第8期1151-1154,共4页
Chemical Industry and Engineering Progress
基金
长江学者和创新团队发展计划资助(IRT0532)
新世纪人才支持计划项目(NCET-04-0498)
关键词
Γ-癸内酯
树脂吸附
转化分离耦合
γ-decalactone
resin adsorption
conversion integrated with separation
