摘要
目的探讨蒙古族高血压的遗传环境影响因素。方法在现况调查基础上,以其中无血缘关系的579名蒙古族人（高血压者298人,正常血压者281人）为研究对象进行病例对照研究。调查相关的环境因素并采集血样,对肾素基因一处新发现的插入/缺失（insertion/deletion,I/D）多态性、血管紧张素转换酶基因的插入/缺失（ivseaion/deletion.I/D）多态性,采用PCR技术结合凝胶电泳和银染方法进行基因分型。采用非条件Logistic回归模型进行遗传、环境多因素分析。结果年龄、体质指数（BMI）、每日饮酒量、肾素基因I/D多态性对高血压的发生差异有统计学意义（P〈0.05）。年龄每增加10岁发生高血压的危险性是增加前的1.28倍（OR95%CI=05～1.57）;BMI≥24 kg/m^2发生高血压的危险性是BMI〈24 kg/cm^2的2.44倍（OR95%CI=1.66～3.64）;每日饮酒量每增加一个等级发生高血压的危险性是增加前的1.61倍（OR95%CI=1.25～2.08）;肾素基因I/D多态性以II基因型为参照,ID、DD基因型的OR分别为2.39（OR95%CI=1.31～4.48）,2.41（OR95%CI=1.27～4.68）。结论超重或肥胖、长期过量饮酒是蒙古族人群高血压的危险因素,肾素基因I/D多态性D等位基因可增加蒙古族人群高血压的危险性。
Objective To explore the impact of genetic and environmemtal factors on essential hypertension （EH）in Mongolian of China. Methods On the basis of prevalence survey, 579 Mongolian people, 298 hypertensives and 281 normotensives, who had no blood relationship each other, were selected as subjects to conduct case-control study. All the subjects were interviewed with questionnaire and their blood specimens were collected. Renin gene insertion/deletion（REN gene I/D） polyrnorphism. Angiotensin converting enzyme gene insertion/deletion （ACE genel/D）polymorphism were genotyped with polymerase chain reaction （PCR）, polyacrylamide gel electrophoresis and silver staining. Results Multivariate Logistic regression analysis showed that age, BMI, amount of alcohol drunk per day, Renin gene I/D polymorphism were statistically significant factors on essential hypertension （ P 〈 0.05 ）. Conclusion Overweight or obesity, over alcohol consumption are risk factors of EH in Mongolian population in China. Renin gene I/D polymorphism D alleles may increase risk of EH in Mongolian population in China.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2007年第9期1075-1077,共3页
Chinese Journal of Public Health
基金
国家自然科学基金(30271149)
关键词
蒙古族
高血压
遗传因素
环境因素
Mongolian
essential hypertension
genetic factors
environmental factors
