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雌激素保护胰岛β功能的作用机制研究进展 被引量：3

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摘要 雌激素保护胰岛β功能，减少糖尿病的发生。研究其作用的分子机制，将为探索开发新的治疗药物提供基础研究依据。
作者 彭彦孟（综述） 甘立霞（审校）
机构地区 第三军医大学生物化学与分子生物学教研室
出处 《国际检验医学杂志》 CAS 2007年第8期719-719,722,共2页 International Journal of Laboratory Medicine
基金 国家自然科学基金（30570888） 国家自然科学基金（30670998） 全军十一五医药卫生基金（06H025）
关键词 雌激素 糖尿病 胰岛Β细胞
分类号 R457.4 [医药卫生—治疗学]
  • 相关文献

参考文献7

  • 1Wild S, Roglic G, Green A, et al. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030 [J]. Diabetes Care, 2004, 27(5): 1047-1053.
  • 2Rossouw JE, Anderson GL, Prentice RI., et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial [J]. JAMA, 2002 J, 288(3) : 321-333.
  • 3毛季萍.雌激素与高血糖及其临床问题[J].实用糖尿病杂志,2006,2(5):7-8. 被引量：5
  • 4Godsland IF. Oestrogens and insulin secretion [J]. Diabetologia, 2005, 48(11): 2213-2220.
  • 5Simpson ER, Misso M, Hewitt KN, et al. Estrogen--the good, the bad, and the unexpected [J]. Endocr Rev, 2005, 26(3): 322-330.
  • 6Le-May C, Chu K, Hu M, et al. Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice [J]. Proc Natl Acad Sci USA, 2006, 103(24) : 9232- 9237.
  • 7Bryzgalova G, Gao H, Ahren B, et al. Evidence that oestrogen receptor-alpha plays an important role in the regulation of glucose homeostasis in mice: insulin sensitivity in the liver [J]. Diabetologia, 2006, 49(3): 588-597.

二级参考文献11

  • 1Galipeau D, Verma S, Mcneill JH. Female rats are protected against fructose- induced changes in metabolism and blood pressure. Am J Physiol Heart Circ Physlol 2002;283(6) :H2478 - 2784.
  • 2Ivandic A, Prpic - Krizevac I, Bozic D, et al. Insulin resistance and androgens in healthy women witlh different body fat distributions[J].Wien Kiln Wochenschr 2002 May, 15;114(8-9):321-326.
  • 3Rossouw J E, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial.JAMA 2002;288:321- 333.
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  • 10Andersson B, MattSson LA, Hahn L, et al. Estrogen replacement therapy decreases hyperandrogerLicity and improves glucose homeostasis and plasma lipids in postmenopausal women with noninsulin-independent diabetes mellitus.J Clin Endocrinol Metab 1997;82(2):638 - 643.

共引文献4

同被引文献39

  • 1俞兰,石福彦.性激素与Ⅱ型糖尿病的关系及其作用机制[J].内蒙古医科大学学报,2008,30(S2):122-126. 被引量：1
  • 2[1]HALBAN P A.Cellular sources of new pancreatic beta cells and therapeutic implications for regenerative medicine[J].Nat Cell Biol,2004,6(11):1021-1025.
  • 3[2]RHODES C J.Type 2 diabetes-a matter of beta-cell life and death?[J].Science,2005,307(5708):380-384.
  • 4[3]MARCHETTI P,DOTTA F,LAURO D.An overview of pancreatic beta-cell defects in human type 2 diabetes:implieations for treatment[J].Regul Pept,2008,146(1-3):4-11.
  • 5[4]PRENTKI M,NOLANET C J.Islet beta cell failure in type 2 diabetes[J].J Clin Invest,2006,116(7):1802-1812.
  • 6[5]LE MAY C,CHU K,HU M,et al.Estrogens protect pancreatic beta-cells from apeptesis and prevent insulin-deficient diabetes mellitus in mice[J].Proc Natl Acad Sci USA,2006,103(24):9232-9237.
  • 7[6]GEISLER J G,ZAWALICH W,ZAWALICH K,et al.Estrogen can prevent or reverse obesity and diabetes in mice expressing human islet amyloid polypeptide[J].Diabetes,2002,51:2158-2169.
  • 8[7]BRYZGALOVA G,GAO H,AHREN B,et al.Evidence that oestrogen receptor-alpha plays an important role in the regulation of glucose homeostasis in mice:insulin sensitivity in the liver[J].Diabetologia,2006,49(3):588-597.
  • 9[8]WEINAND S,JAHR H,HERING B J,et al.Oxygen radical production in human mononuclear blood cells is not suppressed by drugs used in clinical islet transplantation[J].J Mol Med,1999,77(1):121-122.
  • 10[9]ECKHOFF M D,CHRISTOPHER E,CHERYL A,et al.Enhanced isolated pancreatic islet recovery and functionality in rats by 17β-estradiol treatment of brain death donors[J].Surgery,2004,136(2):336-345.

引证文献3

二级引证文献14

国际检验医学杂志
2007年 第8期

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