摘要
目的:研究荆防挥发油对炎症相关因子表达和调节的影响。方法:用OA和LPS2次打击,建立2次打击急性肺损伤(ALI)模型。荆防挥发油(45.19μL.kg-1)对大鼠ALI模型支气管上皮细胞间黏附分子CD54,肺组织核因子-κB(NF-κB)p65、支气管上皮细胞中NF-κB p65 mRNA的组织化学观察及统计。结果:荆防挥发油能明显抑制CD54的表达、NF-κB p65的活化及阻止NF-κB p65 mRNA的转录增加。结论:荆防挥发油抑制CD54的表达,减少p65蛋白的合成可能是其抗炎的分子机制之一。
Objective： To study the effects of volatie oil of F. schizonepeta herb and D. saposhnikovia root （OSS） on proinflammatory cytokine expression and regulation in rats. Method： OA and LPS were injected intravenously to rats to develop ALI. The rats were treated with OSS （45. 19 μL. kg^-1 ）. The pathological sections of lung tissue were prepared and observed in acute lung injury rats. The expression of nuclear factor-kappa B p65 （ NF-κB p65）, intercellar adhesion molecule CD54, and NF-κB p65 mRNA were determined in lung cells. Result： volatie oil of F. schizonepeta herb and D. saposhnikovia root significantly inhibited the expression of CD54, the activation of NF-κB p65, and the transcription of NF-κB p65 mRNA. Conclusion： OSS can reduce the expression of CD54 and NF-κB p65 protein synthesis, which may be its anti-inflammatory molecular mechanisms.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2007年第17期1777-1779,共3页
China Journal of Chinese Materia Medica
关键词
荆防挥发油
细胞间黏附分子CD54
核因子-ΚB
P65
volatie oil of Fineleaf schizonepeta herb and Divaricate saposhnikovia root
CD54
nuclear factor-kappa B p65
