摘要
胰岛素样生长因子-I(I nsulin-like growth factor-I,I GF-I)是机体生长、发育和代谢的一个重要调控因子,同时也是生长激素(growth hormone,GH)启动生长活性的主要介导者。血液中的I GF-I主要来源于肝脏,以内分泌的形式作用于其他组织;许多肝外组织也能合成I GF-I,其主要以自分泌或旁分泌的形式发挥作用。多种因素调控其表达。本文就猪I GF-I的表达与调控方面的最新研究进展进行一综述。
Insulin-like growth factor-Ⅰ（IGF-Ⅰ） is an important regulator of growth, development, metatabolism, and is the primary mediator of the growth-promoting activity of growth hormone（GH） in mammals. The primary source of IGF-Ⅰ is the liver, from which IGF-Ⅰ is released into the blood and acts in an endocrine mode on other tissues. IGF-Ⅰ is also synthesized in many extrhepatic tissues, where it functions in an autocrine or paracrine manner. IGF-Ⅰ gene expression is controlled by many factors. This article reviewed the latest research progress of expression and regulation of the pig IGF-Ⅰ gene.
出处
《家畜生态学报》
2007年第4期90-92,共3页
Journal of Domestic Animal Ecology
基金
国家振兴东北老工业基地科技攻关项目(2004BA907A22)资助
关键词
猪
胰岛素样生长因子-Ⅰ
表达
调控
pig
insulin-like growth factor-Ⅰ
expression
regulation
