摘要
目的:制备格列喹酮固体分散体并考察其体外溶出性。方法:以聚乙烯吡咯烷酮K30(PVP)、聚乙二醇6000(PEG)为载体,溶剂熔融法和溶剂法制备格列喹酮固体分散体,并与原料药比较体外溶出度。结果:载体比例越大,药物溶出愈快。载体为PVP所制固体分散体的体外溶出行为总体优于载体为PEG者。格列喹酮-PVP固体分散体(1∶7)10min内体外溶出度达到70%以上,优于格列喹酮原料药。结论:成功制备了格列喹酮固体分散体。
OBJECTIVE： To prepare gliquidone solid dispersion and to investigate its dissolution rate. METHODS： The gliquidone solid dispersion was prepared by dissolvent - fusion method and dissolvent method with PEG - 6000（PEG） and PVP K30（PVP） as carriers. RESULTS： The results of in vitro dissolubility test showed that the higher the carrier ratio, the faster the drug dissolution. The in vitro dissolubility of solid dispersions was faster with PVP than with PEG as carrier. The dissolution rate of the gliquidone- PVP （1 ： 7） solid dispersion reached as high as above 70% in 10 minutes, which was superior to that of its bulk drug. CONCLUSION： The gliquidone solid dispersion has been prepared successfully.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第25期1955-1957,共3页
China Pharmacy
