摘要
目的探讨制备硫酸沙丁胺醇脉冲缓释片的方法。方法用粉末直接压片法制备片心,干压包衣技术制备脉冲缓释片。正交试验优选处方,对最优处方进行体外释放度验证。结果脉冲缓释片迟滞时间为2￣3h,迟滞后药物释放符合Higuchi方程。结论硫酸沙丁胺醇脉冲缓释片处方设计和工艺方法可行,质量稳定。
Objective To explore the methods that how to prepared salbutamol sulfate pulse sustained-release tablets. Methods The core tablets were prepared by direct compression. The pulse sustained-release tablets were prepared by a kind of coating technique called dry-powder compression. The optimal prescription was selected by orthogonal design.The best prescription was authenticated by in vitro release determination. Results The lag time was 2 to 3h. The drug release profile in vitro after lag time conform to Higuchi equation. Conclusion The prescription design and preparation technological process were feasible. The quality was stable.
出处
《食品与药品》
CAS
2007年第09A期8-11,共4页
Food and Drug
关键词
硫酸沙丁胺醇
脉冲
缓释
时辰药理学
salbutamol sulfate
pulse
sustained-release
chronopharmacology
