摘要
[目的]探讨严重烧伤病人持续输注芬太尼镇痛对免疫和应激反应的影响。[方法]20例严重烧伤病人于伤后6 h内入院,随机分为对照组(A组)和静脉输注芬太尼组(B组),每组10例。A组根据病人需要肌注哌替啶50 mg和异丙嗪25 mg,,B组芬太尼10μg/ml+氟哌利多50μg/ml,持续输注量2 ml/h。检测镇痛开始前及开始后6、12、24、48 h的白介素-1β(IL-1β)、白介素-6(IL-6)、肾上腺素(E)和去甲肾上腺素(NE)的水平。[结果]B组病人镇痛开始后IL-1β、IL-6、E和NE较镇痛前水平明显降低(P﹤0.05),且各时点两组间水平差异有显著意义。[结论]严重烧伤病人持续输注芬太尼镇痛可减轻此类病人的免疫抑制和应激反应。
[Objective] To observe the effects of persistent infusion of fentanyl on immune function and stress of patients with severe burn. [Methods] 20 patients hospitalized within 6 hours after severe burn were involved in this study and randomly divided into two groups equally. In group A, the patients received intramuscular injection of Dolantin 50rag and Phenergan 25rag when patients complained of pain, while in group B, combined infusion of Fentanyl 10μg/ml and Droperidol 50μg/ml was given to patients, with the amount of persistent infusion being 2ml/h. The levels of IL-1β, IL-6, epinephrine （E） and norepinephrine （NE） were respectively measured before analgesia and at 6h, 12h, 24h and 48h after analgesia. [ Results] For group B, the patients＇ levels of IL-1 β, IL-6, E and NE were significantly reduced compared with the indexes before analgesia （P〈 0.05）, and these indexes at each time-point in two groups were remarkably different （P〈 0.05）. [Conclusions] Persistent infusion of Fentanyl can relieve the immunosuppression and stress reaction of patients with severe burn.
出处
《现代预防医学》
CAS
北大核心
2007年第17期3223-3224,共2页
Modern Preventive Medicine
关键词
严重烧伤
芬太尼镇痛
免疫
应激
Severe burn
Analgesia with Fentanyl
Immunity
Stress
