摘要
目的探讨肝癌细胞产生的Ⅰ型细胞间粘附分子１（ＩＣＡＭ－１）在肝细胞癌侵袭和转移过程中的作用。方法用原位分子杂交技术检测了３４例原发性肝癌及癌旁组织中ＩＣＡＭ－１ｍＲＮＡ的表达。结果２１例侵袭性生长的肝癌中１９例ＩＣＡＭ－１ｍＲＮＡ表达阳性，明显高于癌旁；１１例伴门静脉癌栓或肝内转移灶形成的肝癌，其癌组织均表达强阳性，癌栓及转移灶表达阳性；而１３例包膜完整的肝癌仅有４例表达阳性。结论肝癌细胞ＩＣＡＭ－１ｍＲＮＡ的表达与肝癌细胞的侵袭及转移相关。
Objecitve\ To study the relationship between the intercellular adhesion molecule 1 (ICAM 1) mRNA expression of hepatocellular carcinoma(HCC)and its invasion and metastasis.Methods\ 34 cases of HCC and their pericarcinomatous tissues were studied on cryostat sections by in situ hybridization to investigate ICAM 1mRNA expression.Results\ The ICAM 1 mRNA expression was stronger in the carcinomatous tissues of 19/21invasive cases than that in the pericarcinomatous tis sues,while in the13non invasive cases,only4exhibited weak ICAM 1mRNA expression.Conclusion\ ICAM 1mRNA expression may correlate with increased risk of invasion and metastasis of HCC.
出处
《中华病理学杂志》
CAS
CSCD
北大核心
1997年第2期82-84,共3页
Chinese Journal of Pathology
关键词
肝肿瘤
胞间粘附分子
肿瘤转移
原位杂交
Liver neoplasms\ \ Intercellular adhesion molecule 1\ \ Neoplasm metastasis\ In situ hybridization
