摘要
背景:肿瘤型M2丙酮酸激酶(M2-PK)是近年发现的一种新型肿瘤标志物。目的:评价粪便肿瘤型M2-PK在胃肠道肿瘤和癌前状态的检测以及肿瘤分期中的意义。方法:以酶联免疫吸附测定(ELISA)检测34例胃癌、31例结直肠癌、19例胃肠道息肉、26例慢性萎缩性胃炎和19例对照者的粪便肿瘤型M2-PK值,胃癌和结直肠癌患者同时行传统外周血肿瘤标志物癌胚抗原(CEA)、糖链抗原(CA)19-9和CA24-2水平检测。结果:胃癌组和结直肠癌组的粪便肿瘤型M2-PK检测值和阳性率均较对照组显著增高(P<0.01),胃肠道息肉组的检测值亦较对照组显著增高(P<0.05)。随着肿瘤临床病理分期的进展和转移的发生.粪便肿瘤型M2-PK检测值逐渐增高(胃癌组:P<0.05;结直肠癌组:P<0.01)。胃癌组和结直肠癌组粪便肿瘤型M2-PK检测的阳性率均显著高于血清CEA、CA19-9和CA24-2(P<0.01)。结论:粪便肿瘤型M2-PK对胃肠道肿瘤和癌前状态之一的胃肠道息肉的诊断有一定临床意义。
Background： Tumor M2 pyruvate kinase （M2-PK） is a novel tumor marker developed in recent years. Aims： To evaluate the significance of fecal tumor M2-PK in the detection of gastrointestinal cancers and precancerous conditions, and in the staging of gastrointestinal cancers. Methods： Thirty-four gastric cancer, 31 colorectal cancer, 19 gastrointestinal polyp, 26 chronic atrophic gastritis and 19 controls were recruited in this study. The concentration of fecal tumor M2-PK was determined by enzyme-linked immunosorbent assay （ELISA）. The traditional peripheral blood tumor markers such as carcinoembryonic antigen （CEA）, carbohydrate antigen （CA） 19-9 and CA24-2 were detected in patients with gastrointestinal cancer simultaneously. Results： The concentration of fecal tumor M2-PK allowed a significant discrimination between gastric cancer and the controls （P〈0.01）, colorectal cancer and the controls （P〈0.01）, and gastrointestinal polyp and the controls （P〈0.05）. The positivity rate of fecal tumor M2-PK was significantly higher in gastric cancer and colorectal cancer groups than that in the controls （P〈0.01）. The clinicopathological staging and metastasis of gastrointestinal cancer significantly affected the level of fecal tumor M2-PK （gastric cancer group： P〈0.05; colorectal cancer group： P〈0.01）. The positivity rate of fecal tumor M2-PK for gastric cancer and colorectal cancer was significantly higher than that of serum CEA, CA19-9 and CA24-2 （P〈0.01）. Conclusions： Fecal tumor M2-PK can be used as a valuable diagnostic marker in gastrointestinal cancer. It might also be useful in the diagnosis of gastrointestinal polyp.
出处
《胃肠病学》
2007年第8期465-468,共4页
Chinese Journal of Gastroenterology
关键词
肿瘤型M2丙酮酸激酶
胃肠肿瘤
癌前状态
诊断试验
常规
Tumor M2 Pyruvate Kinase
Gastrointestinal Neoplasms
Precancerous Conditions
Diagnostic Tests, Routine
