摘要
目的：为探讨中药仙贞片改善糖尿病患者Ｎａ＋－Ｋ＋－ＡＴＰ酶、Ｃａ２＋－Ｍｇ２＋－ＡＴＰ酶活性的作用。方法：观察７２例气阴两虚、肾虚血瘀非胰岛素依赖型糖尿病（ＮＩＤＤＭ）患者（中药仙贞片组）治疗前后Ｎａ＋－Ｋ＋－ＡＴＰ酶、Ｃａ２＋－Ｍｇ２＋－ＡＴＰ酶、全血粘度、血糖及临床症状等的变化。结果：治疗组（中药仙贞片组）疗后Ｎａ＋－Ｋ＋－ＡＴＰ酶．Ｃａ２＋－Ｍｇ２＋－ＡＴＩ”酶活性升高，有显著性意义（Ｐ＜０．０１，Ｐ＜０．０５），全血粘度和临床症状有一定程度的改善，降低血糖的总有效率为空腹血糖（ＦＢＧ）７７．Ｓ％、餐后２ｈ血糖（２°ＰＢＧ）６９．４％；而对照组（安慰剂组）全血粘度及临床症状元显著改善，降低血糖的总有效率为ＦＢＧ．４１．７％、２°ＰＧＢ３８．９％。结论：仙贞片具有改善患者Ｎａ＋－Ｋ＋－ＡＴＰ酶、Ｃａ２＋－Ｍｇ２＋－ＡＴＰ酶活性，改善全血粘度，降低血糖及改善临床症状等作用，为仙贞片治疗气阴两虚、肾虚血瘀ＮＩＤＤＭ患者提供实验依据。
To assess the effect of Xianzhen tablet in treating non-insulin dependent diabetes mellitus (NIDDM).Methods: Seventy-two cases of NIDDM patients with deficiency of both Qi and Yin, deficiency of the Kidney and blood stasis were selected, and the effects of treatment on Na+-K+ -ATPase, Ca2-Mg2+-ATPase, whole blood viscosity, blood sugar and clinical symptoms were observed. Results: After treatment, the treated group showed increased activities that were statistically significant of Na+-K+-ATPase and Ca2+-Mg2+-ATPase (P < 0. 01, P < 0.02) .The whole blood viscosity and symptoms showed improvement to an extent and the total effective rate of blood sugar lowering were as follows f fasting blood glucose(FBG) 77.8%, 2hr. postprandial plasma blood glucose (2hr. postprandial PBG)69.4%. Whereas, the placebo group showed no marked improvement in either whole blood viscosity or symptoms and the total effective rate of blood sugar lowering were FBG 41.7%, 2hr. postprandial PBG:38.9%. CONCLUSION: Xianzhen tablet is effective in improving the activities of Na+-K+-ATPase and Ca2+-Mg2-ATPase, as well as the whole blood viscosity , blood sugar lowering and in improving clinical symptoms, it could treat effectively NIDDM patients with deficiency of both Qi and Yin, deficiency of the Kidney and blood stasis.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1997年第1期13-16,共4页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
糖尿病
中药仙贞片
红细胞膜
治疗
diabetes mellitus
non-insulin dependent
red blood cell membrane
Na+-K+ -ATPase
Ca^2+-Mg^2+-ATPase
whole blood viscosity
