摘要
目的探讨老年2型糖尿病患者骨密度变化及其与胰岛素样生长因子-1(IGF-1)、性激素及各种骨转换因子的相关关系。方法采用单能定量CT(QCT)对53例2型糖尿病(T2DM)患者及40例健康老年人进行脊柱骨密度(BMD)测定,并分析受试者的骨密度与体重指数(BMI)、腰臀比(WHR)、IGF-1、性激素、骨钙素(BGP)、骨特异性碱性磷酸酶(B-ALP)、抗酒石酸酸性磷酸酶-5b(TRACP-5b)等指标间的关系。结果1老年2型糖尿病患者脊柱总BMD低于对照组〔(74.75±22.70)mg/cc vs(88.04±28.29)mg/cc,P<0.05〕。T2DM组血清IGF-1水平低于对照组〔(27.63±5.74)ng/mL vs(32.51±9.68)ng/mL,P<0.05〕。2相关性研究显示,T2DM组IGF-1水平与B-ALP呈正相关(r=0.46,P<0.01),两组受试者IGF-1水平与所测部位BMD均无相关。结论老年2型糖尿病患者存在不同程度骨密度下降;IGF-1水平与骨密度的变化无相关性。
Objective To investigate the changes of bone mineral density（BMD） and the relationship of BMD to serum Insulin-like growth factor-1 concentrations,body mass index（BMI）,waist hip ratio（WHR）,estradiol（E2）,testosterone（T）,biochemical markers of bone turnover as well as other factors in the elderly individuals with Type 2 diabetes mellitus（T2DM）.Methods BMDs of spine were measured by quantitative CT for patients with T2DM（n=53） and health controls（n=40）.The relationships of BMD related to serum Insulin-like growth factor-1 concentrations,BMI,WHR,E2,T,bone Gla protein,bone alkaline phosphatase,tartrate resistant acid phosphatase 5b levels were also analyzed.Results The spine BMD values for the T2DM patients were significantly reduced when compared with controls（（74.75±22.70） mg/cc vs（88.04±28.29） mg/cc,P〈0.05）,and the concentration of serum Insulin-like growth factor-1 in T2DM group was significantly lower than that in control（（27.63±5.74） ng/mL vs（32.51±9.68） ng/mL,P〈0.05）.The level of serum Insulin-like growth factor-1 was positive correlation to bone-specific alkaline phosphatase（B-ALP） in the T2DM patients（r=0.46,P〈0.01）.Conclusion The spine BMD in elderly T2DM patients is lower than that in control group.The circulating serum Insulin-like growth factor-1 does not have a significant influence on bone mass in elderly T2DM patients.
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2007年第5期832-835,共4页
Journal of Sichuan University(Medical Sciences)
关键词
胰岛素样生长因子-1
单能定量CT
骨密度
糖尿病
2型
Insulin-like growth factor-1 Quantitative computed tomography Bone density Diabetes mellitus,type 2
