摘要
乳房外Paget病是一种少见的皮肤上皮性肿瘤。采用免疫组化技术发现多种免疫表型在该肿瘤中表达,如:细胞角蛋白、黏蛋白、巨囊性病的液状蛋白、上皮膜抗原、癌胚抗原、人表皮生长因子受体2等。这些不同的免疫表型在探讨该肿瘤的组织来源、诊断、鉴别诊断、判断预后及指导治疗方面具有不同的价值。研究认为Toker细胞、乳腺样腺等亦可能为该肿瘤的来源;MUC1+/HER2+提示高侵袭性;根据免疫表型的差异更有助于"皮肤型"和"内胚层型"的诊断,以便于推测组织来源并判断预后。
Extramammary Paget＇s disease （ EMPD ） is a rare intracpithclial neoplasm of skin. Immunohistochcmistry technique has revealed that many immune markers express in EMPD, such as cytokcratins, mucin, gross cystic disease fluid protein-15 （ GCDFP-15 ）, epithelial membrane antigen （EMA）, carcinocmbryonic-likc antigen （ CEA ）, human epidermal growth factor receptor 2 （ HER2 ）, etc. These immune markers arc usually of different values to the clarification of EMPD origin, diagnosis, differential diagnosis, speculation of EMPD prognosis, and gnidc to EMPD management. Recent studies indicate that Tokcr cells and mammary-like gland arc likely candidates for the histogenesis of EMPD. The expression of MUC 1 and HER2 often suggests a strong capability of invasion of EMPD. The difference in immunophcnotypcs may benefit the differential diagnosis of ＂cutaneous＂ and ＂cndodcrmal＂ EMPD as well as speculation about its origin and prognosis.
出处
《国际皮肤性病学杂志》
2007年第5期308-310,共3页
International Journal of Dermatology and Venereology
关键词
佩吉特病
乳腺外
皮肤肿瘤
免疫组织化学
Paget＇ s discasc,cxtramammary
Skin neoplasms
Immunohistochcmistry
