摘要
目的系统评价含左氧氟沙星的三联方案补救根除幽门螺杆菌的疗效和耐受性。方法检索Medline、Embase、Cinahl,检索词为(Helicobacter pylori或H.pylori)和(levofloxaxin或fluoru- quinolones或quinolones),检索中国生物医学文献数据库(CBM-disc),检索词为"幽门螺杆菌和左氧氟沙星"或"幽门螺杆菌和喹诺酮"。筛选比较含左氧氟沙星的三联方案和含铋剂的四联方案的根除幽门螺杆菌补救治疗随机对照试验,进行荟萃分析,进而评价研究质量,提取数据计算根除率和不良反应率。结果共有7项随机对照试验符合入选标准,含左氧氟沙星的10d三联方案Hp根除率高于含铋剂的7d四联方案(86.9%比61.8%,P<0.01),不良反应率或严重不良反应率低于后者(16.8%比37.1%,P<0.01;0.41%比12.1%,P<0.01),耐受性较好。含左氧氟沙星的7d三联方案疗效与含铋剂的7d四联方案相当(71.4%比78.6%,P=0.2d)。结论含左氧氟沙星的10d三联方案补救根除的疗效和耐受性均优于含铋剂的7d四联方案。
Objective To systematically review the efficacy and tolerance of levofloxacin-based rescue regimens for H. pylori eradication failures. Methods A search of Medline, Embase, Cinahl, CBM-dise was performed. Randomized controlled trials comparing levofloxaein-based triple therapy with bismuth-based quadruple therapy were selected for meta-analysis. Assessment of study quality and extracting data to calculate eradication rate and side effect rate. Results Seven randomized controlled studies met the inclusion and exclusion criteria were recruited. Ten-day levofloxaein-based triple therapy was more effective（86.9% vs 61.8% P 〈 0. 01） and better tolerated than 7-day bismuth-based quadruple therapy and with a lower incidence of side effect（16. 8%vs 37. 1%/40 P M 0. 01） and serious side effect （0.41% vs 12. 1% P 〈 0.01）. There is no difference of eradication rate between 7-day levofloxaein- based triple regimen and 7-day bismuth-based quadruple regimen. Conclusions A 10-day course levo- floxaein triple therapy is more effective and better tolerated than 7-day bismuth-based quadruple therapy in the rescue treatment for H. pylori eradication.
出处
《中华消化杂志》
CAS
CSCD
北大核心
2007年第8期534-537,共4页
Chinese Journal of Digestion
基金
上海市重点学科建设资助项目(Y0205)
关键词
氧氟沙星
螺杆菌
幽门
药物疗法
联合
荟萃分析
Ofloxaein
Helieobaeter pylori
Drug therapy, combination
Meta-analysis
