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C肽与2型糖尿病慢性并发症的相关性 被引量：3

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摘要 C肽又称连接肽，是胰岛素原转变为胰岛素过程中的裂解产物。长期以来一直认为C肽没有生物活性，只能用于评估糖尿病患者残留的内源性胰岛素分泌功能，但近年来大量的研究显示C肽具有多种生物活性，特别在改善血管及神经功能方面发挥着重要作用。本研究旨在了解C肽对于2型糖尿病患者慢性并发症的影响，探索其临床应用的前景。
作者 顾鸣宇 赵立 彭永德
机构地区 上海交通大学附属第一人民医院内分泌科
出处 《上海医学》 CAS CSCD 北大核心 2007年第8期631-632,共2页 Shanghai Medical Journal
关键词 糖尿病慢性并发症 C肽 2型 胰岛素分泌功能 胰岛素原 生物活性 糖尿病患 裂解产物
分类号 R587.2 [医药卫生—内分泌]
  • 相关文献

参考文献9

  • 1Wahren J,Ekberg K,Samnegard B,et al.C-peptide:a new potential in the treatment of diabetic nephropathy.Curr Diab Rep,2001,1:261-266.
  • 2Ido Y,Vindigni A,Chang K,et al.Prevention of vascular and neural dysfunction in diabetic rats by C-peptide.Science,1997,277:563-566.
  • 3孙蔚,高鑫,崔大敷,夏其昌.C肽对12周STZ大鼠糖尿病肾病的干预作用[J].复旦学报（医学版）,2002,29(5):338-342. 被引量：2
  • 4Vague P,Coste TC,Jannot MF,et al.C-peptide,Na+,K+ATPase,and diabetes.Exp Diabesity Res,2004,5:37-50.
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二级参考文献14

  • 1[1]Johansson BL, Sjoberg S, Wahren J. The influence of human C-peptide on renal function and glucose utilization in type 1 ( insulin-dependent) diabetic patients. Diabetologia, 1992,35:121
  • 2[2]Johansson BL, Kemell A, Sjoberg S, et al. Influence of combined Cpeptide and insulin administration on renal function and metabolic control in diabetes Type 1. J Clin Endocrinol Metab, 1993,77:976
  • 3[3]Johansson BL, Femqvist-Forbes E, Kernell A, et al. Combined Cpeptide and insulin treatment improves renal and nerve function in IDDM patients. Diabetologia, 1995,38:19
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  • 6[6]Samnegard B,Jacobson SH,Jaremko G, et al. Effects of C-peptide on glomerular and renal size and renal function in diabetic rats. Kidney Iht, 2001,60:1258
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  • 9[9]Rigler R,Pramanik A,Jonasson P, et al. Specific binding of proinsulin C-peptide to human cell membranes. Proc Natl Acad Sci USA, 1999,96:13318
  • 10[10]Ido Y,Vindigni A,Chang K, et al. Prevention of vascular and neural dysfunction in diabetic rats by C-peptide. Science, 1997, 277:563

共引文献1

同被引文献31

  • 1孟东,于德民,陈樱,汪玮琳,曲小红,尹潍.C肽和胰岛素对高糖诱导的内皮细胞凋亡的影响[J].中华内分泌代谢杂志,2005,21(1):30-31. 被引量：9
  • 2洪世华,肖常青.C肽与糖尿病并发症关系的研究进展[J].内科,2006,1(2):152-153. 被引量：4
  • 3李菁爽,詹晓蓉,阴慧清,刘昊凌.C肽对糖尿病大鼠肾脏的影响[J].现代生物医学进展,2007,7(4):577-579. 被引量：5
  • 4王茹.C肽的研究进展及作用机制[J].中国厂矿医学,2007,20(3):291-293. 被引量：3
  • 5Manzella D, Raqno E, Abbatecola A M, et al. Residual C- peptide secretion and endothelial function in patients with type 2 diabetes[J]. Clin Sci,2003,105(1) :113-118.
  • 6Scalia R, Coyle K M, Levine B J, et al. Cpeptide inhibits leukocyte endothelium interaction in the microcirculation during acute endothelial dysfunction[J]. FASEB J, 2000,14 ( 14 ) : 2357- 2364.
  • 7Bratcher A P, Rodriguez W E, Tyagi S C, et al. Mechanisms of endothelial dysfunction with development of type 1 diabetes mellitus role of insulin and C-peptide[J]. Cell Biochem,2005,96 (6) : 1149-1156.
  • 8Johansson B L, Sundell J, Ekberg K, et al. C peptide improves adeno sine induced myocardial vasodilation in type 1 diabetes patients[J]. Am J Physiol Endocrinol Metab, 2004, 286 (1) :E14-19.
  • 9Walcher D, Aleksic M, Jerg V, et chemotaxis of human CD4 positive pertussis toxin sensitive G proteins and phosphoinositide 3 kinase[J]. Diabetes,2004,53(7) : 1664-1670.
  • 10Johansson B L,Kernell A,Sjoberg S,et al.Influence of combined C-peptide and insulin administration on renal function and metabolic control in diabetes type1[J].J Clin Endocrinol Metab,1993,77(4):976-981.

引证文献3

二级引证文献26

上海医学
2007年 第8期

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